Hoffmann-la Roche Inc.

F. Hoffmann-la Roche Ag

Martin Graf

Roberto Iacone

Eric Argirios Kitas

Cornelia Hertel

Thilo Enderle

Eva Christina Thoma

Sannah Jensen Zoffmann

Ravi Jagasia

Christoph Patsch

Jacques Bailly

Klaus Christensen

Vanessa Hunt

Osele Ciampi

This application relates to non-human primate (NHP) induced pluripotent stem cell (IPSC)-derived hepatocytes, for example, Cynomolgus monkey () induced pluripotent stem cell-derived hepatocytes, and methods of producing the same. Moreover, this application relates to methods of using NHP IPSC-derived hepatocytes for drug screening, drug safety assessment and in models of infection.

Non-human primate induced pluripotent stem cell derived hepatocytes and uses thereof

This application relates to a method for differentiating somatic cells into multi-competent neural crest cells based on linked steps of chemically defined medium inductions. Neural crest cells are able to differentiate into numerous cell types like Schwann cells, chondrocytes, smooth muscle cells or adipocytes.

Small molecule based conversion of somatic cells into neural crest cells

This application relates to a method for differentiating pluripotent stem cells (PSCs) into multi-competent renal precursor cells expressing Six2. These renal precursor cells are able to differentiate into fully functional and fully differentiated podocytes. Moreover this application relates to a method for differentiating human embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) into defined renal precursor cells expressing Six2 and podocytes based on linked steps of chemically defined medium inductions.

Method for differentiation of pluripotent stem cells into multi-competent renal precursors

This application relates to a method for converting somatic cells to Neural Stem Cells (NSCs). Moreover this application relates to a method for converting human fibroblasts, keratinocytes or adipocytes to neural stem cells based on linked steps of genes transduction and chemically defined medium induction.

Conversion of somatic cells to induced reprogrammed neural stem cells (irNSCs)

The present invention relates to a fluorescently labeled growth hormone secretagogue which can be used for the identification of compounds capable of binding to growth hormone secretagogue receptors, in particular by high throughput screening.

Fluorescently labeled growth hormone secretagogue

Growing community of inventors

Zeiningen, Switzerland

Martin Graf