Alteon Incorporated

Synvista Therapeutics, Inc.

Martin Gall

Edmond Joseph LaVoie

Stanley Charles Bell

Dilip R Wagle

John J Egan

Sara Vasan

Miguel Pagan

Provided is a method of treating or ameliorating or preventing glaucoma, decreasing intraocular pressure or improving or amemliorting ocular accommodation in an animal, including a human comprising administering an intraocular pressure decreasing or accommodation improving amount of a compound of the formula I: 

Method for treating glaucoma IC

Provided, among other things, is a method of treating or ameliorating or preventing an indication of the invention in an animal, including a human comprising administering an effective amount of a compound of the formula I: 

Method for treating fibrotic diseases and other indications

Disclosed herein are novel methods for reducing or preventing the harmful effects of solar radiation on skin. Also disclosed are novel sunscreen compositions comprising thaizolium, thiadiazolium or triazolium compounds or derivatives and analogs thereof for reducing or preventing the harmful effects of solar radiation on skin. Sunscreen active agents that provide UV-A and UV-B filters are also included. The invention further discloses additional sunscreen active agents, emollients, humectants, dry-feel modifiers, waterproofing agents, insect repellants, antimicrobial preservatives, antioxidants, chelating agents, fragrances and moisturizers, suitable carriers for topical application and emulsions.

Sunscreen compositions and methods of use thereof

Provided is a method of treating or ameliorating a number of indications in an animal, including a human, comprising administering an effective amount of a compound of the formula I or IA,wherein J is oxygen, sulfur, or N&#x2014;R.

Method for treating fibrotic diseases or other indications utilizing thiazole, oxazole and imidazole compounds

Provided, among things, is a method of decreasing intraocular pressure in an animal, including a human, comprising administering an intraocular pressure decreasing amount of a compound of the formula IA and or IB:

Method for treating glaucoma V

Provided, among things, is a method of decreasing intraocular pressure in an animal, including a human, comprising administering an intraocular pressure decreasing amount of a compound of the formula I:

Method for treating glaucoma VI

Method for treating fibrotic diseases or other indications IIC

Provided is a method of treating or ameliorating hypertension in an animal comprising administering an effective amount of a compound of formula I:

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Morristown, NJ, United States of America

Martin Gall