4sc Ag

Takeda Gmbh

Nycomed Gmbh

Martin Feth

Bernd Mueller

Rolf-Peter Hummel

Thomas Maier

Beate Schmidt

Geert Jan Sterk

Armin Hatzelmann

Hans-Peter Kley

Degenhard Marx

Christof Zitt

Christian Scheufler

Andrea Wohlsen

Wiro M P B Menge

Anke Heuser

Matthias Müller

Johannes A M Christiaans

Deborah Ockert

Thomas Beckers

Thomas Baer

Jürgen Volz

Thomas Bär

Juergen Volz

Bernd Müller

Matthias Mueller

Matthias MÜLLER

The compound 1-(2-{4-[3-(3,4-dimethoxyphenyl)-4,4-dimethyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl]piperidin-1-yl}-2-oxoethyl)pyrrolidine-2,5-dione is a novel effective inhibitor of the type 4 phosphodiesterase useful in the treatment of psoriasis or atopic dermatitis.

Pyrazolone derivatives as PDE4 inhibitors

The compound 1-(2-{4-[3-(3,4-dimethoxyphenyl)-4,4-dimethyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl]piperidin-1-yl}-2-oxoethyl)pyrrolidine-2,5-dione is a novel effective inhibitor of the type 4 phosphodiesterase.

A salt of (E)-N-{2-amino-phenyl)-3-{1-[4-(1-methyl-1 H-pyrazol-4-yl)-be&#x3c0;zenesulfonyl]-1 H-pyrrol-3-yl)-acrylamide selected from the group consisting of the hydrobromide, methansulfonate, hemi ethane-1,2-disulfonate, benzenesulfonate, toiuenesulfonate and 2-naphthalenesulfonate.

(E)-N-(2-amino-phenyl)-3-{1-[4-(l-methyl-1H-pyrazol-4-yl)-benzenesulfonyl]-1H-pyrrol-3-yl}-acrylamide salts

The compounds of a certain formula 1, in which R1, R7, R8, R9 and n have the meanings as given in the description, are novel effective inhibitors of the type 4 phosphodiesterase.

Compounds of a certain formula I, in which R1, R2, R3, R4, R5, R6 and R7 have the meanings indicated in the description, as well as salts thereof are novel effective HDAC inhibitors.

Sulphonylpyrroles as inhibitors of HDACs novel sulphonylpyrroles

Sulphonylpyrrole hydrochloride salts as histone deacetylases inhibitors

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Kelkheim-Hornau, Germany

Martin Feth