Syngenta Crop Protection, Inc.

Basilea Pharmaceutica Ag

Sandoz Gmbh

Novartis Animal Health Us, Inc.

Takeda Pharmaceutical Company Limited

Novartis Corporation

Martin Eberle

Felix Bachmann

Fritz Schaub

Subho Roy

Alessandro Strebel

Goutam Saha

Gerald Wayne Craig

Sudhir Srivastava

Saleem Farooq

Daniel Stierli

Hugo Ziegler

Werner Zambach

Andr&eacute; Jeanguenat

Arthur Steiger

Christian Pillonel

Harald Walter

Daniel Obrecht

Stephan Trah

Peter Grootenhuis

Soan Cheng

Martin Zeller

Fredrik Cederbaum

Anatol Luther

William Lutz

Philipp Ermert

Anita Schnyder

Rohit Saxena

Peter Ackermann

Urs Müller

Urs Mueller

Frank Lach

Allessandro Strebel

Subir Kumar Sadhukhan

Peter Stanetty

Steven Scott Bondy

Daniel Dennis Comer

Julie Elizabeth Penzotti

Jürg Ehrler

Godhuli Nandi

Clemens Lamberth

The invention relates to novel substituted 2-(phenyl-, pyridyl- or pyrimidyl-carbonyl)-furanes and -thiophenes and related phenoxy/phenylthio-acetophenones and corresponding heterocyclic compounds, processes for the preparation thereof, pharmaceutical compositions containing same, the use thereof optionally in combination with one or more other pharmaceutically active compounds for the therapy of neoplastic diseases and autoimmune diseases, and a method for the treatment of such a diseases.

Aroylfuranes and aroylthiophenes

The invention relates to novel substituted 3-phenylamino-5-(3-aminophenyl)pyridines and corresponding pyrazines of formula (I), wherein A is CH or N, Rrepresents C(&#x2550;O)R, S(&#x2550;O)R, P(&#x2550;O)(OR), optionally substituted phenyl or optionally substituted heteroaryl, and the other substituents have the meaning described in the specification, processes for the preparation thereof, pharmaceutical compositions containing same, the use thereof optionally in combination with one or more other pharmaceutically active compounds for the therapy of neoplastic diseases and autoimmune diseases, and a method for the treatment of such a diseases.

Phenylaminopyridines

The invention relates to compounds of formula (I) wherein R represents aryl or heteroaryl, X is oxygen, a carbonyl group, an oxime derivative of a carbonyl group or an &#x3b1;,&#x3b2;-unsaturated carbonyl group, and the substituents Rto Rhave the meanings given in the specification, for use as medicaments, to novel compounds of formula (I), to methods of synthesis of such compounds, to pharmaceutical compositions containing compounds of formula (I), to the use of a compounds of formula (I) for the preparation of a pharmaceutical composition for the treatment of neoplastic and autoimmune diseases, and to methods of treatment of neoplastic and autoimmune diseases using such compounds of formula (I) or of pharmaceutical compositions containing same

Furazanobenzimidazoles

The invention relates to compounds of formula (I) wherein R represents aryl or heteroaryl, X is a bond, a carbonyl group, a derivative of a carbonyl group, an ethylene group or an ethylenecarbonyl group, Ris optionally substituted amino or hydroxy, and the substituents Rto Rhave the meanings given in the specification, to methods of synthesis of such compounds, to pharmaceutical compositions containing compounds of formula (I), to intermediates, to the use of a compounds of formula (I) as a medicament and for the preparation of a pharmaceutical composition for the treatment of neoplastic and autoimmune diseases, and to methods of treatment of neoplastic and autoimmune diseases using such compounds of formula (I) or of pharmaceutical compositions containing same.

Substituted benzimidazoles and their use for inducing apoptosis

The invention relates to compounds of formula (I) wherein Rrepresents aryl, aralkyl or heteroaryl, Ris aryl or heteroaryl and Ris aryl, heteroaryl or optionally substituted aminomethyl, to methods of synthesis of such compounds, to pharmaceutical compositions containing compounds of formula (I), to the use of a compounds of formula (I) for the preparation of a pharmaceutical composition for the treatment of neoplastic and autoimmune diseases, and to methods of treatment of neoplastic and autoimmune diseases using compounds of formula (I) or of pharmaceutical compositions containing same.

Sulfopyrroles

The invention relates to compounds of formula (I) wherein R represents aryl or heteroaryl, X is oxygen, a carbonyl group, an oxime derivative of a carbonyl group or an &#x3b1;,&#x3b2;-unsaturated carbonyl group, and the substituents Rto Rhave the meanings given in the specification, for use as medicaments, to novel compounds of formula (I), to methods of synthesis of such compounds, to pharmaceutical compositions containing compounds of formula (I), to the use of a compounds of formula (I) for the preparation of a pharmaceutical composition for the treatment of neoplastic and autoimmune diseases, and to methods of treatment of neoplastic and autoimmune diseases using such compounds of formula (I) or of pharmaceutical compositions containing same 

The invention relates to &#x3b1;-sulfonylamino-acetonitrile derivatives of the general formula (I) including the optical isomers thereof and mixtures of such isomers, wherein Ar, and Arindependently of each other stand for an optionally substituted aryl or heteroaryl group, R, and Rstand independently of each other for hydrogen, optionally substituted C,-Calkyl, optionally substituted C-Calkenyl, C-Calkynyl or optionally substituted C-Ccycloalkyl; Rdesignates hydrogen, C-Calkenyl, C-Calkynyl or optionally substituted C,-Calkyl; Ris optionally substituted C,-Calkyl, optionally substituted C-Calkenyl, C-Calkynyl or optionally substituted C-Ccycloalkyl; Rand Rare independently of each other hydrogen or optionally substituted C-Calkyl, optionally substituted C-Calkenyl, C-Calkynyl or optionally substituted C-Ccycloalkyl; R, and Rare independently of each other hydrogen or optionally substituted C,-Calkyl, optionally substituted C-Calkenyl, C-Calkynyl or optionally substituted C-Ccycloalkyl; W designates a bridge selected from &#x2014;O&#x2014; &#x2014;S(O)m&#x2014; or &#x2014;NR&#x2014;; X designates a direct bond or a bridge selected from &#x2014;O&#x2014;, &#x2014;S(O)m&#x2014; or &#x2014;NR&#x2014;; a and b independently of each other stand for a number 1, 2 or 3; and c and m independently of each other stand for a number zero, 1 or 2. These compounds possess useful plant protecting properties and may advantageously be employed in agricultural practice for controlling or preventing the infestation of plants by phytopathogenic microorganisms, especially fungi.

Alpha-sulfonylamino-acetonitriles

The present invention relates to a method of protecting plants against attack or infestation by phytopathogenic organisms, such as nematodes or especially microorganisms, preferably fungi, bacteria and viruses, or combinations of two or more of these organisms, by applying at least one compound of the formula (I): wherein n is 0 or 1, Ris halogen, alkoxy, haloalkyl, haloalkoxy or alkyl, Ris hydrogen, halogen, alkyl, haloalkyl, alkoxy or haloalkoxy, each of R, Rand Ris, independently of the others, hydrogen, lower alkyl or halogen, and Ris as defined in claimThe invention also relates to new compounds of formula (I), their preparation, use and compositions comprising said compound 

N-phenyl-4-(4-pyridyl)-2-pyrimidineamine derivatives

Compounds of formula (I), or a salt thereof, wherein R, R, R, R, R, R, R, and Rare specified organic redicals; and compositions containing them, processes for making them and their use as fungicides. 

Thiazolyl substituted aminopyrimidines as plant protection agents

The invention relates to novel N-phenyl-4-(4-pyridyl)-2-pyrimidineamine derivatives of the general formula (I) wherein the sum of (m+p) together is 0, 1, 2 or 3; n and q are independently of each other 0 or 1, and the sum of (m+p+q) together is 1, 2, 3 or 4; Ris hydrogen, halogen, alkoxy, haloalkyl, haloalkoxy or alkyl; Ris hydrogen, C&#x2013;C-alkyl, C&#x2013;C-haloalkyl or C&#x2013;C-alkoxy; Ris hydrogen, C&#x2013;C-alkyl, C&#x2013;C-alkenyl or C&#x2013;C-alkynyl; each of R, R, Rand Ris, independently of the others, hydrogen, C&#x2013;C-alkyl, C&#x2013;C-haloalkyl, hydroxy-C&#x2013;C-alkyl or C&#x2013;C-alkoxy-C&#x2013;C-alkyl, or the ring members CRRor CRRor CRRare independently of each other a carbonyl group (C&#x2550;O) or a group C&#x2550;S; X is C&#x2550;O, C&#x2550;S, S&#x2550;O or O&#x2550;S&#x2550;O; Y is O, S, C&#x2550;O, CH, &#x2014;N(R)&#x2014;, &#x2014;O&#x2014;N(R)&#x2014;, &#x2014;N(R)&#x2014;O&#x2014; or NH&#x2014;; Ris hydrogen, C&#x2013;C-alkyl, C&#x2013;C-alkenyl, C&#x2013;C-alkynyl, &#x2014;CHOR, CHSR, &#x2014;C(O)R, &#x2014;C(O)OR, SO2R, SORor SR; and Ris C&#x2013;C-alkyl, C&#x2013;C-alkoxyalkyl, C&#x2013;Chaloalkyl or phenylC&#x2013;C-alkyl wherein the phenyl may be substituted by up to three groups selected from halo or C&#x2013;C-alkyl; or a salt thereof. The invention also relates to the preparation of the compounds and to agrochemical compositions comprising at least one of those compounds as active ingredient as well as the preparation of the said compositions and to the use of the compounds or of the compositions in controlling or preventing the infestation of plants by phytopathogenic microorganisms, especially fungi.

Microbiocidal N-phenyl-N-[4-(4-pyridyl-2-pyrimidin-2-yl]-amine derivatives

Compounds of general formula (I) wherein the substituents are as defined in claimare suitable for use as herbicides

Organic compounds

Pesticidal triazine-derivatives

Pesticidal pyrimidine-derivatives

Trifluoromethylpyrrolcarboxamides

Growing community of inventors

Bottmingen, Switzerland

Martin Eberle