Biochemie Gesellschaft M.b.h

Sandoz Gmbh

Sandoz Ag

Nabriva Therapeutics Ag

Martin Decristoforo

Johannes Ludescher

Hubert Sturm

Werner Veit

Andreas Berger

Josef Wieser

Siegfried Wolf

Andreas Hotter

Arthur Pichler

Ingolf Macher

Herbert Schleich

Ludwig Miller

A process for the preparation of 14-O&#x2014;[(N-(3-methyl-2-amino-butyryl-piperidinyl)sulfanyl)acetyl]mutilins of formula feasible for large-scale production of high purity products, and wherein the carbon atom at the piperidine ring attached to the sulphur atom is either in the (S)-configuration or in the (R)-configuration, and a new crystalline form of 14-O&#x2014;[(N-3-methyl-2-(R)-amino-butyryl-piperidine-3(S)-yl)sulfanyl)acetyl]mutilin-hydrochloride.

Pleuromutilins and process for the preparation of pleuromutilins

The present invention relates to crystalline form C of Tigecycline dihydrochloride and to methods for the preparation of the same. Furthermore the present invention relates to the use of crystalline form C of Tigecycline dihydrochloride as an intermediate for the preparation of an anti-infective medicament. Moreover the present invention relates to pharmaceutical compositions comprising crystalline form C of Tigecycline dihydrochloride in an effective amount and to the use of crystalline form C of Tigecycline dihydrochloride as an anti-infective medicament.

Crystalline form C of tigecycline dihydrochloride and methods for its preparation

Process for purification of a cephalosporin derivative

Process for production of ceftiofur

Crystalline 2-(amninothiazol-4-yl)-2-(tert.butoxycarbonylmethoxyimino)acetic acid-S-mercapto-benzo-thiazolylester in form of an N,N-dimethylacetamide solvate; a crystalline salt of a 7-&lsqb;2-(aminothiazol-4-yl)-2-(carboxymethoxyimino)acetamido&rsqb;-3-vinyl-3-cephem-4-carboxylic acid with an amine of formula N(R,)(R,)(R,), wherein R,, R,, and R,have various meanings, a crystalline sulphuric acid addition salt of a 7-&lsqb;2-(2-aminothiazol-4-yl)-2-carboxymethoxyimino)acetamido&rsqb;-3-vinyl-3-cephem-4-carboxylic acid; and the use of these salts in the production of cefixime, e.g. in form of a trihydrate.

Purification process

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Kramsach, Austria

Martin Decristoforo