Zeneca Limited

Syngenta Crop Protection, Inc.

Syngenta Corporation

Syngenta Participations Ag

David Anthony Jackson

Ben Brockbank

Martin Charles Bowden

Andrew Edmunds

Stephen Martin Brown

Michael Drysdale Turnbull

Trevor R Perrior

Alfred Glyn Williams

Brian David Gott

Alexandre Christian Saint-Dizier

Iacob Eremia Gutu

Martin Zeller

Andrew John Blacker

Gottfried Seifert

John David Jones

Beat Jau

Fanny Giordano

Dominik Faber

George Robert Hodges

Douglas John Smith

Keith Moorhouse

Juerg Wiss

David Drouard

Martin Brown

Thomas Aitcheson Clark

Hans-Dieter Schneider

Fanny Delphine Brigtte Giordano

Iacob Eremia Gutsu

The present invention relates to novel processes for the production of compounds of formula wherein Hal and Hal' are independently selected from Cl and F, and Ris selected from Cl, F and H.

Processes for the preparation of pyrazoles

The invention relates to a process for the preparation of intermediates useful in the preparation of fungicidally active phenylpropargylether derivatives. The process involves coupling of carboxylic acid with an amine in (a) the absence of a catalyst; (b) the presence of a boronic acid catalyst. 

Processes for the preparation of amides

The present invention relates to novel processes for the production of compounds of formula (I) wherein Hal and Hal' are independently selected from Cl and F, and Ris selected from Cl, F and H. 

The invention relates to a process for the preparation of fungicidally active compounds such as tricyclic amine derivatives (I). The process involves coupling of a carboxylic 5 acid e.g. a compound of formula (II) with an aniline, e.g. a compound of formula (III) in the presence of a boronic acid catalystor an antimony catalyst (II)(III)(I) wherein R1, R2, R3, R4, R5, R6, R7, X, Y and Het are defined in the specification. 

Process for the preparation of amides

A process for the preparation of a compound of formula (I), the process comprising: (i) the reaction of a compound of formula (III), with a compound of formula (IV) to give a compound of formula (II), and (ii) the reaction of the compound of formula (II) with a leaving group, to give the compound of formula (I).

Process for the synthesis of mandipropamid and derivatives thereof

The present invention relates to a process for the preparation of compounds of formula (I), wherein the substituents are as defined in claim, by reacting a compound of formula (II), with a bromine or chlorine source to form a compound of formula (III), wherein X is chlorine or bromine; reacting that compound with water to form the compound of formula (IV), converting that compound, using a compound of formula (V), wherein Mis the hydrogen cation or an alkali metal ion, alkaline earth metal ion or ammonium ion, into the compound of formula (VI), and treating that compound with a cyanide source in the presence of a base. 

Process for the production of cyclic diketones

The present invention relates to a process for the preparation of compounds of formula (I), wherein the substituents are as defined in claimby reacting a compound of formula (II), either with a chlorination or bromination agent or with a compound of formula (III) CI&#x2014;SOR, Rbeing C-Calkyl, C-Chaloalkyl, phenyl or C-Calkyl-substituted phenyl, to form the compound of formula (IV), reacting the compound of formula (IV) with a compound of formula (V) M-O&#x2014;C(O)&#x2014;Y wherein Y is as defined above and Mis the hydrogen cation or an alkali metal ion, alkaline earth metal ion or ammonium ion, to form the compound of formula (VI) and treating that compound with a cyanide source in the presence of a base. 

The present invention relates to a process for the preparation of compounds of formula (I) wherein the substituents are as defined in claim, by reaction of a compound of formula (II) wherein Ris C-Calkyl or C-Ccycloalkyl and Rand Rare as defined for formula (I), with a compound of formula (III) wherein R, R, Rand X, are as defined for formula (I) in claim, in an inert solvent in the presence of a proton source. 

Process for the production of substituted nicotinic acid esters

A process for the preparation of 3,5-dichloropyridine comprising reacting a trichloropyridine, a tetrachloropyridine or pentachloropyridine with zinc metal, in the presence of an acidic compound and at a temperature in the range 50-120&deg; C.

Chemical process

A process for preparing a compound of formula (IV), wherein R,is C,alkyl, CH,(C,haloalkyl), benzyl, CH,(C,akenyl or CH,(C,alkynyl), which comprises reducing a compound of formula (III). Compounds of formula (IV) are agrochemical intermediates.

Process for the preparation of 8-azabicyclo(3.2.1)octane derivatives

A process for preparing a compound of formula (IV) wherein R,is C,alkyl, C,haloalkyl, benzyl, C,alkenyl or C,alkyny, (provided that the &agr;-carbon atom of R,is neither unsaturated nor substituted with halogen), which comprises reacting a compound of formula (III) with a source of hydroxylamine in the presence of an acid. Compounds of formula (IV) are agrochemical intermediates.

Process for the preparation of substituted 8-azabicyclo&lsqb;3,2,1&rsqb;octanes

5-Chloro-2-(4,4-difluorobutylthio)thiazole is prepared from 2-mercaptotriazole by a multistep process involving S-alkylation, chlorination and dehydrochlorination and is converted by oxidation to the corresponding sulfone which is useful as an agricultural nematicide.

Process

The present invention provides the novel chlorofluorohydrocarbon 1,1-difluoro-1,4-dichlorobutane, and a process for its preparation comprising reacting 1,1,1,4-tetrachlorobutane or 1,1,4-trichlorobut-1-ene with hydrogen fluoride in the liquid or vapor phase. The product has useful solvent properties and is also useful in synthetic chemistry for the introduction of fluorocarbon functionality.

Chlorofluorohydrocarbon and process thereto

5-Chloro-2-(4,4-difluorobutenylthio)thiazole is prepared from 2-mercaptothiazole by a multistep process involving S-alkylation, chlorination and dehydrochlorination and is converted by oxidation to the corresponding sulfone which is useful as an agricultural nematicide.

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Brighouse, United Kingdom

Martin Charles Bowden