The Brigham and Women's Hospital, Inc.

Beth Israel Hospital Assn.

Beth Israel Hospital

Martin C Carey

Jeffrey S Flier

Alan C Moses

Methods and compositions for removing bilirubin from the gastrointestinal tract are described. The compositions contain a zinc salt in a form that is insoluble in the gastrointestinal tract. The methods and compositions are useful for treating patients that have disorders associated with an elevated concentration of bilirubin including, for example, gallstone related disorders.

Methods and compositions for inhibiting enterohepatic cycling of

Compositions and methods useful for the prevention or treatment of a human or animal disorder or for the regulation of the human or animal physiological condition are provided. The compositions used comprise, in admixture, a biologically-effective amount of a drug specific for the disorder or condition and a biocompatible, water-soluble, amphiphilic steroid, other than a natural bile salt, which is capable of increasing drug permeability of the human or animal body surface across which the drug is to be administered, in an amount effective to increase the permeability of the surface to the drug.

Drug administration

Compositions and methods useful for the prevention or treatment of a human or animal disorder or for the regulation of a human or animal physiological condition are provided. The compositions used comprise, in admixture, a biologically-effective amount of a drug specific for the disorder or condition and a biocompatible, water-soluble, amphiphilic steroid, other than a natural bile salt, which is capable of increasing drug permeability of the human or animal body surface across which the drug is to be administered, in an amount effective to increase the permeability of the surface to the drug.

A composition useful for the treatment of an animal suffering from a predetermined medical disorder including, in admixture, a medically effective amount of a drug, other than an antibiotic, effective against the medical disorder, and a biocompatible, water-soluble, amphiphilic steroid, other than a bile salt, which is capable of increasing the permeability to the drug of a surface of the animal across which the drug is to be administered, in an amount effective to increase the permeability of the surface to the drug.

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Wellesley, MA, United States of America

Martin C Carey