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Hopsteiner-hallertauer Hopfenveredelungsgesellschaft M.b.h.

Hallertauer Hopfenveredelungsgesellschaft M.b.h.

Aigner, Ludwig

Martin Biendl

Herbert Riepl

Ludwig Aigner

Sébastien Couillard-Despres

Francisco Javier Rivera

Corinna Urmann

Ludger A Wessjohann

Eleni Priglinger

Eleni Oberbauer-Hofmann

Heike Wilhelm

Hans Becker

Aslieh Nookandeh

Sébastien Couillard-despres

The present invention relates to certain chromane-like cyclic prenylflavonoids, in particular the compounds of formulae (I), (II) and (III) as described and defined herein, for use in the treatment or prevention of a neurological disorder, as well as their use in promoting neuronal differentiation, neurite outgrowth and neuroprotection. 

Chromane-like cyclic prenylflavonoids for the medical intervention in neurological disorders

The present invention relates to an efficient method for producing naringenin derivatives from xanthohumol or derivatives thereof. In particular, the method according to the present invention provides the production of isoxanthohumol, for example also in enantiomer-enriched form, from xanthohumol and subsequent demethylation of isoxanthohumol according to specific procedures obtaining corresponding naringenin derivatives, such as, in particular, 8-prenylnaringenin.

Method for producing naringenin derivatives from xanthohumol

A process is specified by which the xanthohumol present in hops can be isolated in high yield in an economical manner. In the process an ethanol pure resin extract is first extracted with a liquid or supercritical solvent in which the xanthohumol is insoluble and the resultant extraction residue is first washed with a first solvent mixture and then the extraction residue which has been washed with the first solvent mixture is, after removing the first solvent mixture, extracted with a second solvent mixture, the first solvent mixture having a higher polarity than the second solvent mixture. The hop extract produced from the second solvent mixture has a xanthohumol content of at least 85% by weight.

Process for producing xanthohumol present in hops and xanthohumol-rich hop extract obtainable thereby

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Elsendorf, Germany

Martin Biendl