Bayer Aktiengesellschaft

Martin Beuck

Stefan Wohlfeil

Ulrich E Muller

Rudolf H Hanko

Johannes-Peter Stasch

Andreas Knorr

Stanislav Kazda

Peter Fey

Matthias Muller-Gliemann

Thomas Kramer

Walter Hubsch

Jurgen Dressel

Dirk Denzer

Hilmar Bischoff

Siegfried Zaiss

Siegfried Goldmann

Richard D Connell

Rudi Grutzmann

Ozkan Yalkinoglu

Anke Domdey-Bette

Ulrich M&uuml;ller

Rudi Gr&uuml;tzmann

Matthias M uller-Gliemann

Ulrich E M Uller

Claudia Hirth-Dietrich

J Urgen Dressel

Siegfried Raddatz

Michael Matzke

Ulrich Niewohner

Thomas Kr Amer

Walter H Ubsch

Klaus-Helmut Mohrs

Christoph Gerdes

James J Elting

Klaus Mohrs

Stefan Lohmer

Rolf Angerbauer

Erwin Bischoff

Klaus Frobel

Hans-Georg Dellweg

Jan-Bernd Lenfers

Ulrich Müller

Rudi Grützmann

Walter Husch

Stanisiav Kazda

Hans-Peter Belleman

Rudi Gr Utzmann

Hans-Peter Bellemann

Cycloalkano-indole and -azaindole derivatives are prepared by reaction of appropriately substituted carboxylic acids with amines. The cycloalkano-indole and -azaindole derivatives are suitable as active compounds for medicaments, preferably antiatherosclerotic medicaments.

Cycloalkano-indole and -azaindole derivatives

Cycloalcanoindole and -azaindole derivatives are prepared by reaction of appropriately substituted carboxylic acids with anmines. The cycloahloanindole and -azaindole derivatives are suitable as active compounds for medicaments, preferably antiatherosclerotic medicaments.

The hetero-linked phenylglycinolamides are prepared by reaction of the corresponding hetero-linked phenylacetic acids with appropriate phenylglycinols. The hetero-linked phenylglycinolamides are suitable as active compounds in medicaments.

Hetero-linked phenylglycinolamides

The heterocyclically substituted phenylglycinolamides are obtained by reaction of heterocyclically substituted phenylacetic acids with appropriate phenylglycinols. The heterocyclically substituted phenylglycinolamides are suitable as active compounds in medicaments, in particular in antiatherosclerotically active medicaments.

Heterocyclically substituted phenylglycinolamides

Cycloakano-indole and -azaindole derivatives are prepared by reaction of appropriately substituted carbonylic acids with amines. The cycloalkano-indole and -azaindole derivatives are suitable as active compounds for medicaments, preferably antiatherosclerotic medicaments.

The phenylcyclohexylcarboxamides, some of which are known, are suitable as active compounds in medicaments, in particular in medicaments for the treatment of restenosis.

Use of phenylcyclohexylcarboxamides

The heterocyclic aryl-, alkyl- and cycloalkylacetamides are prepared by reacting the appropriately substituted acetic acids with amines, if appropriate in complexed form. The heterocyclic aryl-, alkyl- and cycloalkylacetamides can be used as active compounds in medicaments, in particular in antiatherosclerotic medicaments.

Heterocyclic aryl-, alkyl- and cycloalkylacetamides

Trisubstituted biphenyls are prepared by reacting corresponding pyridones with biphenylmethyl halogen compounds. The trisubstituted biphenyls can be employed as active compounds in medicaments.

Trisubstituted biphenyls

Heterotricyclically substituted phenyl-cyclohexanecarboxylic acid derivatives are prepared by reacting the heterocyclic compounds with cyclohexanecarboxylic acid derivatives which are substituted by benzyl halide radicals. The compounds can be employed as active compounds in medicaments.

Heterotricyclically substituted phenyl-cyclohexane-carboxylic acid

The invention relates to phenylacetic acid derivatives which are substituted by a five-membered nitrogen heterocycle bonded via an N atom. They are prepared by reaction of phenylacetic acid derivatives substituted with leaving groups with the appropriate nitrogen heterocycles and can be used as active substances in medicaments for the treatment of high blood pressure and atherosclerosis.

Heterocyclically substituted phenylacetic acid derivatives and their use

Benzyloxy-substituted phenylglycinolamides are prepared by reaction of benzyloxy-substituted phenylacetic acids with phenylglycinols. The benzyloxy-substituted phenylglycinolamides are suitable as active compounds in medicaments, in particular in medicaments for the treatment of atherosclerosis.

Benzyloxy-substituted phenylglycinolamides

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Erkrath, Germany

Martin Beuck