Pierre Fabre Medicament

Compagnie Generale Des Etablissements Michelin

Armines

Association Pour La Recherche Et Le Developpement Des Methodes Et Processus Industriels

Martial Sauceau

Bernard Freiss

Jacques Fages

Hubert Lochard

Jean-Jacques Letourneau

Jose Merino Lopez

Frédéric Pialot

Christophe Joussot-Dubien

Nathalie Coste

Florence Marciacq

A process for manufacturing rubber crumb comprises the following steps: (a) suspending rubber granules having a given size in an autoclave () containing a supercritical fluid; (b) agitating the mixture for a predetermined time at constant pressure and constant temperature; (c) carrying out an isenthalpic expansion of the mixture from step (b) by spraying it through a nozzle ().

Method for producing rubber crumb, and rubber crumb

The invention relates to a method for the preparation of soluble molecular complexes, comprising one or more active substances which are poorly-soluble in an aqueous medium, included within one or more host molecules, characterized in comprising the following steps: (a) bringing one or more active substances into contact with one or more host molecules, (b) carrying out a molecular diffusion step by bringing a dense fluid into contact, under pressure, with the mixture obtained in (a), in static mode, in the presence of one or more diffusion agents and (c) recovery of the molecular complex thus formed.

Method for the preparation of molecular complexes

The invention concerns a method for preparing compounds for interaction of an active substance hardly soluble in an aqueous medium with a porous support. The invention is characterized in that it comprises the following steps: (a) mixing the active substance generated by supercritical fluid and the specific amount of porous support; (b) carrying out a molecular diffusion step by contacting in static mode a supercritical fluid with the mixture obtained at step (a) for the time required to improve the dissolution in the aqueous medium of the mixture obtained at step (a); (c) washing the interactive compound obtained at step (b) with a supercritical fluid flow; (d) recuperating the particles of the interactive compound thus formed. The invention also concerns a compound obtainable by said method.

Method for preparing a compound of interaction of active substances with a porous support using supercritical fluid

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Saint Juery, France

Martial Sauceau