Centre National De La Recherche Scientifique

Institut Gustave Roussy

Université Paris Sud Xi

Institut Pasteur

Université Paris-saclay

Université De Paris-sud Xi

Viroxis

Martial Renard

Thierry Heidmann

Marianne Mangeney

Hugues Bedouelle

Laurent Belkadi

Patrick England

Marie Dewannieux

Therry Heidmann

Described is the use of a mutation of at least one amino acid in the immunosuppressive domain of a HIV or SIV accessory protein, for modulating the immunosuppressive property of the protein.

Mutated HIV Nef for modulating immunity

Mutated viral ENV proteins having mutations in the immunosuppressive domain (ISU) of the transmembrane subunit (TM) have decreased immunosuppressive activity with respect to the wild-type ENV protein. Pharmaceutical compositions that include the protein and nucleic acids coding for the protein are also disclosed.

Mutated env sequence involved in the modulation of the immunosuppressive effect of viral proteins

The present invention relates to a polypeptide having a sequence of 7 to 20 amino acid residues, which is capable of modulating the immunosuppressive properties of a viral protein or a fragment thereof, against the host in which it is expressed (immunosuppression-modulatory sequence) when it substitutes the homologous sequence of the viral protein or fragment, the polypeptide including the minimum following consensus amino acid sequence:XYYYCYXwherein, Xand Xare selected to impact on the immunosuppressive properties, and Yto Yrepresent variable amino acid residues.

Polypeptide sequence involved in the modulation of the immunosuppressive effect of viral proteins

The invention relates to biosensors, methods for obtaining them and their use for detecting, assaying or locating, in direct immunofluorescence, a ligand such as an antigen or hapten, in a heterogeneous population. The biosensor includes (i) at least one fragment of a receptor which is protein in nature, capable of binding to a ligand via an active site, where at least one amino acid residues of the fragment located in the proximity of the active site is naturally present in the form of a cystein (Cys) residue, or is substituted with a Cys residue, and (ii) a fluorophore coupled to the Cys residue.

Biosensors, method for obtaining the same and uses thereof

The invention relates to biosensors, methods for obtaining them and their use fro detecting, assaying or locating, in direct immunofluorescence, a ligand such as an antigen or hapten, in a heterogeneous population. The biosensor includes (i) at least one fragment of a receptor which is protein in nature, capable of binding to a ligand via an active site, where at least one amino acid residues of the fragment located in the proximity of said active site is naturally present in the form of a cystein Cys residue, or is substituted with a Cys residue, and (ii) a fluorophore coupled to the Cys residue.

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Paris, France

Martial Renard