Esteve Quimica S.a.

Marti Bartra Sanmarti

Salvador Puig Torres

Laura Coppi

Montserrat Monsalvatje Llagostera

Montserrat Closa Clavo

Jaime Tomas Navarro

Jaime Thomas Navarro

Montserrant Monsalvatje Llagostera

The process for obtaining quinapril hydrochloride (I) comprises the stages of: a) hydrogenolysis of the benzyl ester of quinapril (II) by treatment in an alcoholic solvent, with concentrated hydrochloric acid or a solution of hydrogen chloride in isopropanol, and hydrogenation; b) removal of the solvent; c) addition of toluene to precipitate the quinapril hydrochloride as a toluene solvate; d) treatment of said solvate with a Class 3 solvent which forms a solvate of quinapril hydrochloride from which it can be removed by drying without degrading; and e) drying of the solvate from step d) to yield quinapril hydrochloride (I), an antihypertensive agent.

Process for obtaining quinapryl hydrochloride and solvates useful for isolating and purifying quinapryl hydrochloride

The invention relates to the new crystalline forms II, III and V of meloxicam; to the processes for obtaining the crystalline forms I, II, III and V; and, finally, to the interconversion processes of the forms II, III, IV and V into the form I.

Crystalline forms of meloxicam and processes for their preparation and interconversion

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Barcelona, Spain

Marti Bartra Sanmarti