Portland State University

Elex Biotech, Inc.

Martha Sibrian-Vazquez

Robert Michael Strongin

Jorge Omar Escobedo-Cordova

Mark Allen Lowry

Lei Wang

Jialu Wang

Jorge O Escobedo Cordova

Josephrajan Thainashmuthu

Douglas Boatman

Jorge O Escobedo-CÓRDOVA

This disclosure concerns compounds and a method for modulating the activity of calcium ion channels, including Ca-induced (or Ca-activated) calcium release channels and conformationally coupled calcium release channels such as ryanodine receptors. Some of the compounds have a structure according to formula I, or a stereoisomer, tautomer, hydrate, solvate, prodrug, or pharmaceutically acceptable salt thereof. 

Compounds for treatment of cardiac arrhythmias and heart failure

Embodiments of methods and compounds for isolating and detecting lysophosphatidic acids (LPAs) are disclosed. Kits for performing the methods also are disclosed. LPAs are isolated from biological samples by liquid-liquid extraction followed by solid phase extraction. LPA species may be separated by HPLC, and the separated species may be identified and quantified. Also disclosed are embodiments of compounds capable of universally detecting a plurality of LPA species with substantially equivalent sensitivity. Embodiments of the disclosed compounds are useful for determination of total LPA concentration in a sample comprising a plurality of LPA species without separation of individual LPA species.

Lysophosphatidic acid detection

Molecular probes for detecting and imaging pancreatic cancer are disclosed. The probes are modified benzoxanthene fluorophores, which are selectively taken up by pancreatic cancer cells, such as pancreatic ductal adenocarcinoma cells. Embodiments of the disclosed probes are useful for pancreatic cancer detection, therapeutic monitoring, and/or image-guided surgery.

Molecular probes for detection and imaging of pancreatic cancer

Embodiments of templated polymeric materials capable of binding lysophosphatidic acids (LPAs) are disclosed. Methods of making and using the templated polymeric materials also are disclosed. The disclosed templated polymeric materials are molecularly imprinted polymers that bind LPAs and facilitate the production of lysophosphatidic acid-enriched samples, for instance through extraction of lysophosphatidic acids from biological samples, such as plasma or serum samples.

Enrichment of lysophosphatidic acids with templated polymeric materials

Embodiments of compounds for selectively detecting an analyte are disclosed, along with methods and kits for detecting analytes with the compounds. The compounds are bridged viologen conjugates including at least one fluorophore according to the general structure  At least one of R/R, R/R, R/R, R/R, R/R, and/or R/Rtogether form a substituted or unsubstituted cycloalkyl or aryl.

Analyte detection using near-infrared fluorophores

Embodiments of near-infrared (NIR) dyes are disclosed, along with methods and kits for detecting analytes with the NIR dyes. The NIR dyes have a structure according to the general structure At least one of R/R, R/R, R/R, R/R, R/R, and/or R/Rtogether forms a substituted or unsubstituted cycloalkyl or aryl.

Near-infrared fluorescent dyes with large stokes shifts

Embodiments of compounds for selectively detecting a thiol are disclosed. In some embodiments, the compounds are bridged viologens, and the compounds are capable of reacting with homocysteine and/or glutathione in a buffered solution to produce a change in the solution's absorbance spectrum and/or emission spectrum. Also disclosed are embodiments of methods and kits for detecting homocysteine and/or glutathione with the disclosed bridged viologens.

Growing community of inventors

Portland, OR, United States of America

Martha Sibrian-Vazquez