Pfizer Corporation

Martha L Minich

Subas Man Sakya

Hengmiao Cheng

Kristin M Lundy

Jin Li

Andrei Shavnya

Peter Bertinato

Kiyoshi Kawamura

Kazuo Ando

Brian S Bronk

Chikara Uchida

Tomoki Kato

Bryson Rast

Kristin Lundy DeMello

Subas M Sayka

The present invention relates to heterocyclo alkylsulfonyl pyrazoles of the formula I: wherein the ring of the formula (R)&#x2014;A&#x2014;(SOR), m, X, Rthrough Rare as defined in the specification, to pharmaceutical compositions containing them and to their medicinal use. The compounds of the invention are useful in the treatment or alleviation of inflammation and other inflammation associated disorders, such as arthritis, colon cancer, and Alzheimer's disease in mammals, preferably humans, dogs, cats and livestock animals.

Heterocyclo-alkylsulfonyl pyrazoles

The present invention relates to 5-heteroatom-substituted pyrazoles of the formula I:

5-heteroatom-substituted pyrazoles

Efficient synthesis of 5-heteroatom-containing -pyrazoles

Heteroaryl phenyl pyrazole compounds as anti-inflammatory/analgesic agents

5-heterocyclo-pyrazoles

Heterocyclo-alkylsulfonyl pyrazole derivatives as anti-inflammatory/analgesic agents

This invention relates to compounds of formulas 1 and 2 ##STR1## and to pharmaceutically acceptable salts and solvates thereof, wherein X, X.sup.1, R.sup.1, R.sup.2, R.sup.7, R.sup.17 and R.sup.19 are as defined herein. The compounds of formulas 1 and 2 may be useful in the treatment of bacterial, parasitic and protozoal infections, as well as disorders related to bacterial, parasitic and protozoal infections, in mammals, fish and birds. The invention also relates to pharmaceutical compositions containing the compounds of formula 1 and 2 and to methods of treating bacterial, parasitic and protozoal infections by administering the compounds of formula 1 and 2.

3,6-ketal and enol ether macrolide antibiotics

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Gales Ferry, CT, United States of America

Martha L Minich