Cephalon, Inc.

Marta Szabat

Anthony Gerard Doyle

Adam Clarke

Matthew Pollard

Lynn Dorothy Poulton

Bridget Ann Cooksey

Julia Rozenfeld

Mark Terence Liddament

Anna Mikaela Bracken

Anna Maria Matilda Quigley

The present disclosure provides antibodies and antigen-binding fragments thereof that specifically bind to human PAR-2 and compositions comprising such antibodies or antigen-binding fragments thereof. In a particular aspect, the antibodies or antigen-binding fragments thereof that specifically bind to human PAR-2 block the interaction between a PAR-2 activating ligand and an extracellular domain of PAR-2, and/or blocks PAR-2 activation by a PAR-2 activating ligand, In further aspects, the antibodies or antigen-binding fragments can be used to treat diseases or conditions associated with increased expression of PAR-2 and/or diseases or conditions that can be alleviated by antagonizing activation of PAR-2 by a PAR-2 activating ligand (e.g., airway diseases, skin diseases, cancer, orofacial granulomatosis, inflammatory conditions, and pain associated with various diseases or conditions).

Anti-PAR-2 antibodies and methods of use thereof

Growing community of inventors

Vancouver, Canada

Marta Szabat