Richter Gedeon Vegyeszeti Gyar Rt

Marta Kapolnas Nee Pap

Bela Hegedus

Anna Kallay Nee Sohonyai

Laszlo Szporny

Kalman Harsanyi

Elemer Ezer

Ferenc Trischler

Judit Matuz

Eszter Cholnoky

Hajnalka Vikar Nee Petho

Egon Karpati

Gyorgy Hajos

Gyorgy Fekete

Katalin Csomor

Peter Tetenyi

Csaba Kuthi

Andrea Maderspach

Marta Szollosy

Laslo Szporny

Osaba Kuthi

Kalmen Harsanyi

Andres Javor

The invention relates to novel, sulfur-containing 5-substituted benzimidazole derivatives of formula I ##STR1## and acid-addition salts thereof antihyperlipoproteinemic action, a process for preparing the same, pharmaceutical formulations comprising the novel compound as active ingredient and a method for inhibiting atherosclerosis, trombus formation and treating hyperlipoproteinemic diseases.

Antihyperlipoproteinemic 5-substituted sulfur-containing benzimidazole

New intermediate compounds of the formula (I) are disclosed ##STR1## wherein R is hydrogen or C.sub.1 to C.sub.4 alkyl;

2-hydroxy-and 2-halo-ethylthiopyridine intermediates for preparing

The compound N-{2-[(3-benzoyl-1-pyridyl)-thio]-ethyl}-N'-cyano-S-methyl-isothiourea and pharmaceutically acceptable acid addition salts thereof are disclosed as well as pharmaceutical compositions containing same and a method of treatment employing same. The compound or its acid addition salts are effective in treating gastric oedema and thus are useful in ulcer therapy.

N-{2-[(3-benzoyl-2-pyridyl)-thio]-ethyl}-N'-cyano-S-methyl-isothiourea,

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Budapest, Hungary

Marta Kapolnas Nee Pap