Hc-pharma Ag

Cerbios-pharma Sa

Marta Castaldi

Graziano Castaldi

Mauro Gaboardi

Marco Baratella

Giuseppe Pallanza

Sara Helmy

Alessandro Baruto

A process for the synthesis of Sofosbuvir is provided comprising the steps of selectively mono-deacetylating a compound of formula (V) enzymatically using a resin supported lipase B derived fromto obtain a compound formula (IV), then converting the compound of formula (IV) to a compound of formula (II) by reacting the compound of formula (IV) with a compound of formula (III), and then converting the compound of formula (II) to Sofosbuvir of formula (I) by deacetylation reaction.

Process for the preparation of sofosbuvir

Sofosbuvir in crystalline Form &#x3b1;, process for its production and use in pharmaceutical compositions.

Sofosbuvir in crystalline form and process for its preparation

The present invention relates to a process for the synthesis of dasatinib and to intermediates useful for its preparation.

Process and intermediates for the preparation of dasatinib

Growing community of inventors

Sizzano, Italy

Marta Castaldi