University of California

California Institute of Technology

The General Hospital Corporation

New York University

The United States Government as Represented by the Department of Veterans Affairs

Buck Institute for Research on Aging

Uroplasty, Inc.

Marshall Leedy Stoller

Robert H Grubbs

Thomas W Kenny

Hoyong Chung

Alissa M Fitzgerald

Renee M Thomas

Cu N Phan

John R Asplin

Brian H Eisner

David Goldfarb

Tom F Lue

Emil A Tanagho

Curtis A Gleason

Richard A Schmidt

Frank L Brodie

Ying Han

Maurice Marcel Garcia

Tiffany Zee

Pankaj Kapahi

Maxwell V Meng

Ryan Hsi

James S Wolf, Jr

This invention related to manufactured microbubbles, as well as methods of using manufactured microbubbles, for example, in medicinal applications. The invention pertains to the physical structure and materials of the microbubbles, as well as to methods for manufacturing microbubbles, methods for targeting microbubbles for specific medicinal applications, and methods for delivering microbubbles in medical treatment.

Targeting microbubbles

A surgical method of cataract fragmentation and extraction via microbubble cavitation is described. In particular, gas-filled microbubbles are injected into a lens capsule of a subject's eye, and cavitation of the microbubbles is activated by applied ultrasound energy. The ultrasound energy can be applied from an external device. The cavitation fragments cataract tissues without damaging other tissue, such as the lens capsule. Fragmented lens material is then aspirated from the lens capsule. The method can be used alone or in conjunction with other methods, such as phacoemulsification.

Method for eye lens removal using cavitating microbubbles

The embodiments disclosed herein relate to a ureteral stent having two stent bodies and a tether. The stent can minimize or prevent migration of the device out of the bladder of the patient while also reducing patient discomfort associated with such stents.

Ureteral stent and related methods

Provided are beverage compositions comprising a urine citrate increasing component and a urine oxalate reducing component. The beverage compositions may be provided in a ready-to-drink form or may be provided in a concentrate form. Also provided are kits comprising the beverage compositions and methods for treating various conditions using the beverage compositions.

Citrate containing beverage

In various embodiments methods and composition are provided for the treatment and/or prophylaxis of cystinuria. In certain embodiments the methods involve administering to a mammal in need thereof (e.g., identified as at risk for, or having cystinuria) an effective amount of lipoic acid and/or one or more lipoic acid derivatives.

Lipoic acid and derivatives thereof for the treatment of cystinuria

This invention provides a novel surgical device well suited to use in laparoscopic or other (e.g. open surgical) procedures. In certain embodiments, the device comprises a surgical probe, including a handle comprising at least one channel passing through the handle; and at least one conduit passing through the handle, where wherein at least one effector element is inserted into or through the channel, which effector element effects one or more surgical functions; and where the conduit comprises a distal conduit port that directs gas out of the conduit to substantially remove debris and/or fluid from a surface disposed proximal to the effector and/or from the effector element.

Device for improved visualization of operative sites during surgery

Active and passive wound drainage systems and method are provided. A drainage device includes an input passage for receiving the fluid from a site on or within the patient's body, a container for holding the fluid, and a reversible valve disposed between the input passage and the container. The reversible valve in an original configuration provides unidirectional fluid flow from the input passage toward the container, and in a reversed configuration provides fluid flow from the container toward the input passage.

Drainage devices and methods

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San Francisco, CA, United States of America

Marshall Leedy Stoller