Sage Therapeutics, Inc.

Marshall Lee Morningstar

Francesco Gerald Salituro

Boyd Lynn Harrison

Maria Jesus Blanco-Pillado

Maria Jesus Blanc-Pillado

Provided herein is a compound of Formula (I) or a pharmaceutically acceptable salt thereof, wherein R, R, R, R, R, R, R, R, R, R, R, R, R, R, R, R, R, R, R, and q are defined herein. L is selected from the group consisting of: wherein A indicates the point of attachment at C17 and wherein X is selected from the group consisting of —C(O)N(R)(R), —N(R)(R), —N(R)C(O)(R), and Rwherein Ris carbon-bound substituted or unsubstituted heteroaryl or substituted or unsubstituted aryl. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I) and methods of using the compounds, e.g., in the treatment of CNS-related disorders.

Neuroactive steroids and their methods of use

Provided herein is a compound of Formula (I) or a pharmaceutically acceptable salt thereof, wherein R, R, R, R, R, R, R, R, R, R, R, R, R, R, R, R, R, R, R, and q are defined herein. L is selected from the group consisting of: wherein A indicates the point of attachment at C17 and wherein X is selected from the group consisting of —C(0)N(R)(R), —N(R)(R), —N(R)C(O)(R), and Rwherein Ris carbon-bound substituted or unsubstituted heteroaryl or substituted or unsubstituted aryl. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I) and methods of using the compounds, e.g., in the treatment of CNS-related disorders.

Provided herein is a compound of Formula (I): or a pharmaceutically acceptable salt thereof, wherein R, R, R, R, R, R, R, R, R, R, R, R, R, R, R, R, R, R, R, R, R, R, Rand n are defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I) and methods of using the compounds, e.g., in the treatment of CNS-related disorders.

Neuroactive steroids and compositions thereof

Provided herein is a compound of Formula (I) or a pharmaceutically acceptable salt thereof, wherein n, R, R, R, R, R, R, R, R, R, R, R, R, R, R, R, R, R, R, R, Rand Rare defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I) and methods of using the compounds, e.g., in the treatment of CNS-related disorders. 

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Framingham, MA, United States of America

Marshall Lee Morningstar