American Home Products Corporation

Marshall A Hayward

Ivo L Jirkovsky

Joseph P Sabatucci

Yvon Lefebvre

Jean Schmid

This invention relates to 4-substituted-5-hydroxy-2(5H)-furanones, to the process for their preparation, to pharmaceutical compositions containing said 4-substituted-5-hydroxy-2(5H)-furanones and to the use of said 4-substituted-5-hydroxy-2(5H)-furanones for modifying the balance between bone production and bone resorption in a host animal, including man.

Inhibition of bone loss by 4-substituted-5-hydroxy-2(5H)-furanones

A method for modifying the balance between bone production and bone resorption in a host animal by administration of (-)-N-[[(5-chloro-benzothiazolyl)-thio]phenylacetyl]-L-cysteine to inhibit bone loss.

Inhibition of bone loss by

A method for modifying the balance between bone production and bone resorption in a host animal by administration of etodolac to inhibit bone resorption.

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Lawrenceville, NJ, United States of America

Marshall A Hayward