Johns Hopkins University

Genetics Institute, Inc.

Marsha Wills-Karp

Clive R Wood

Mary Collins

Debra D Donaldson

Matthew James Whitters

Lori J Fitz

Tamlyn Neben

Shau-Ku Huang

Andrea Keane-Myers

Xiu-Min Li

The present invention is directed to methods for treating asthma.

Method and compositions for treating asthma

Polynucleotides encoding the IL-13 receptor and fragments thereof are disclosed. IL-13 receptor proteins, methods for their production, inhibitors of binding of IL-13 and its receptor and methods for their identification are also disclosed. Methods of medical treatment using such molecules and antagonists of the IL-13/IL-13R interaction are also provided.

Cytokine receptor chain

Administration of an expression gene construct for IFN-.gamma. to an affected organ is an effective means of reversing antigen-induced inflammation. Suitable allergic diseases for treatment include atopic asthma, rhinitis, and dermatitis.

Therapy for allergic diseases

Growing community of inventors

Baltimore, MD, United States of America

Marsha Wills-Karp