Worcester Polytechnic Institute

Case Western Reserve University

Wisconsin Alumni Research Foundation

Kansas State University Research Foundation

Marsha W Rolle

Tanja Dominko

Fioleda Prifti

Terri Anne Camesano

Denis Kole

Eben Alsberg

Christopher Malcuit

Ivan Ding

Anna D Dikina

Amy Peterson

William Leo Murphy

Glenn R Gaudette

Gianluca Fontana

Carol Cramer

Sarah Hernandez

Hannah A Strobel

Pam Weathers

Chris Malcuit

Bernard Binder

Joshua Gershlak

Luis Fabircio Medina-Bolivar

Decellularized plant tissues and the use of these plant tissues as scaffolds are disclosed herein. Particularly, decellularized plant tissues are functionalized such to allow for human cell adhesion, thereby allowing for their use as scaffolds for human cells. These scaffolds can then be used in a number of applications/markets, including as research tools for tissue engineering, regenerative medicine, and basic cellular biology.

Functionalization of plant tissues for human cell expansion

Device, and methods of using or making the device, for engineering cells in vitro are disclosed. In some aspects, a cell culture device comprises at least one glass or polymer surface configured for incubating cells in a culture medium; a charged molecule electrostatically bound to the surface; and a polyelectrolyte multilayer (PEM) electrostatically bound to the charged molecule, the PEM comprising one or more bi-layers of oppositely charged polyelectrolytes, and the PEM having a sufficient thickness to permit release of the charged molecule into the culture medium in a controlled released manner.

Coated cell culture apparatus and methods of use

A modular engineered tissue construct includes a plurality of fused self-assembled, scaffold-free, high-density cell aggregates. At least one cell aggregate includes a plurality of cells and a plurality of biocompatible and biodegradable nanoparticles and/or microparticles that are incorporated within the cell aggregates. The nanoparticles and/or microparticles acting as a bulking agent within the cell aggregate to increase the cell aggregate size and/or thickness and improve the mechanical properties of the cell aggregate as well as to deliver bioactive agents.

Engineered tissue constructs

The invention provides a scaffold of extracellular matrix polymers with recombinant chimeric peptides tethered thereto. The invention also provides recombinant chimeric peptides of antimicrobial peptides and extracellular matrix binding domains. The invention also provides methods for treating chronic wounds using the scaffold and/or recombinant chimeric peptides.

Matrix scaffold with antimicrobial activity

Growing community of inventors

Worcester, MA, United States of America

Marsha W Rolle