Eastman-kodak Company

Johnson & Johnson Clinical Diagnostics, Inc.

Marsha D Oenick

Ignazio S Ponticello

Susan J Danielson

Richard C Sutton

David A Hilborn

Harold C Warren

John Bruce Findlay

Fred T Oakes

Barbara A Brummond

Roy Eugene Snoke

Margaret Elizabeth Logan

Gary L Snodgrass

Carol Anne DeCann

A dry immunoassay analytical element for assaying a ligand, comprising a support bearing:

Reduction in first slide bias and improved enzyme stability by the

The invention is directed to labeled drug hapten analogues comprising:

Immunoassay with novel labeled drug hapten analogues

Biologically active reagents are prepared from particles of copolymers having highly active succinimid groups. The reagents are prepared by covalently attaching biologically active substances, for example antibodies, to the particles, directly or indirectly through amide groups by displacement of highly active succinimid groups on the particle surface. These reagents are used to advantage in analytical elements, methods for the detection of specific binding ligands (such as immunological species) and immunoassays, and in purification methods such as affinity chromatography.

Method of preparing biologically active reagents from

Labeled drug hapten analogues for immunoassays

The invention is directed to new drug hapten analogues comprising:

Drug hapten analogues for immunoassays

Specific binding methods are used for diagnostic assays and purification separations whereby the specific binding capture reagent is prepared from copolymers having highly reactive carboxy groups. These groups are extended from the polymer surface with a linking group having from 8 to 50 atoms in the chain and two or more alkylene, arylene, alkylenearylene or arylenealkylene groups. To these reactive groups is attached a biologically active substance such as a protein or oligonucleotide which then participates in the diagnostic assays or purification separation methods.

Specific binding analytical and separation methods using carboxy

Water-insoluble, noncrosslinking, nonporous copolymers are provided which have recurring units derived from:

Succinimide containing polymers and lattices prepared from same

Biologically active reagents are prepared from particles of copolymers having highly reactive carboxy or equivalent groups. The reagents are prepared by covalently attaching biologically active substances, for example antibodies, to the particles, directly or indirectly through highly reactive carboxy groups on the particle surface. These reagents are used to advantage in analytical elements, methods for the detection of specific binding ligands (such as immunological species) and immunoassays, and in purification methods as affinity chromatography reagents.

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Rochester, NY, United States of America

Marsha D Oenick