Other

Cells for Cells S.a.

Universidad De Los Andes

Regenero S.a.

Wilkens, Camila

Acevedo, Juan Pablo

Rivet, Christopher

Khoury, Maroun

Cells for Cells, S.p.a.

Cells for Cells

Maroun Khoury

Juan Pablo Acevedo

Claudia Brizuela

Daniel Meza Rojas

Camila Wilkens

Ioannis Angelopoulos

Christopher Rivet

Francisca Alcayaga

Rafael Tapia Limonchi

Francisca Alcayaga-Miranda

The invention relates to a method and composition for the cultivation, expansion and production of extracellular vesicles, and the preservation and/or pre-treatment of cells, wherein said composition is a medium or media supplement or a solution comprising pterostilbene or the derivatives thereof, and/or a migration inhibitory factor antagonist and optionally a bivalent cation.

Composition and method for cultivation, expansion, preservation and/or cell pretreatment

The present invention relates to a root canal filler and a dental tissue regeneration method by using the root canal filler.

Composition comprising a substantially pure population of multipotent stromal cells encapsulated in platelet-poor plasma (PPP)

The present invention offers a solution to the lack of an effective alternative method to those already known to treat angiogenesis. In particular, the present invention is the first to show that a substantially pure population of exosomes derived from MenSCs have capacity to reduce tumor angiogenesis in diseases such as prostate cancer, breast cancer and pancreatic cancer. In this sense, the present invention shows that a substantially pure population of MenSCs-derived exosomes reduce the endogenous levels of reactive oxygen species (ROS) in cancer cells and the expression of pro-angiogenic factors such as VEGF, NF-KB, FGF and HIF&#x3b1; in the treated tumors. Overall, the invention offers a promising alternative method to treat angiogenesis. Since it is principally composed of exosomes produced by the Stem cells present in menstrual fluid, the invention provides an ease access and repeated sampling in a non-invasive manner. Such attributes allow the rapid production of the treatment.

Anti-angiogenic therapy based on exosomes derived from menstrual stem cells

The present invention overcomes all the above drawbacks and provides a versatile method for the fabrication of multilayer hollow tubes that uses a layer-by-layer rod dipping approach using different biomaterials. The device enables fine control over fabrication parameters, such as ascending/descending speeds, rod rotational velocity, and crosslinking or polymerization time. All these technologies allows the generation of more complex multilayer hollow tubes such as vessel-like structures, urethral grafting, prostate grafting and the like.

Automated fabrication of layer-by-layer tissue engineered complex tubes

Growing community of inventors

Santiago, Chile

Maroun Khoury