Temple University

Alliance Pharmaceutical Corp.

Other

Peach Technologies LLC

Biopulmonics, Inc.

The Nemours Foundation

Synthetic Gas Solutions, LLC

Marla R Wolfson

Thomas H Shaffer

K Michael Sekins

Robert G Stern

Richard M Franczak

Edward Drew

John N Hoffman

Tariq Rahman

Raymond Foust, Iii

Thomas F Miller

James L Heckman

The present invention provides a respiratory adapter for inhaled media deposition in the lungs and airways. The respiratory adapter provides an inspiratory arm and an expiratory arm, wherein the two arms are joined by a bypass flow bridge. A system of valves, such as one-way valves, directs the flow of gas and media through the respiratory adapter to improve media deposition efficiency and to prevent re-breathing of exhaled gas.

Respiratory adapter and method of use

Systems and methods for assisting respiration extrathoracically, particularly useful for augmenting respiration in neonatal patients, including providing a positive pressure to a torso area of a patient. The positive pressure may be delivered to the torso area of the patient while the torso area is exposed to an ambient pressure, such as by providing positive pressure with high frequency gas jets that are positioned in proximity to the torso area. The positive pressure may be delivered to different parts of the torso area of the patient at different times, such as by controlling gas jets independently. The positive pressure may also be controlled in coordination with a gas flow and concentration to the patient's airway, such as by increasing the positive pressure as a gas flow pressure delivered to the patient's airway is reduced. The gas flow to the patient's airway may be provided by, for example, a high-flow nasal cannula (HFNC) mechanism or a continuous positive airway pressure (CPAP) mechanism that is controlled in coordination with the positive pressure based upon a desired respiratory function of the patient. The control of the gas flow and the positive pressure may be based on an input of patient monitored parameters and/or calculated values based on the patient monitored parameters.

Extrathoracic augmentation of the respiratory pump

A bandage includes a reservoir filled with a perfluorochemical fluid, saturated with oxygen. Oxygen passes through a permeable membrane to the skin or wound to promote healing, and carbon dioxide travels from the skin or wound to the reservoir.

Bandage for facilitating transdermal respiration and healing

Vehicle tires are filled with perfluorocarbon gas to extend tire life.

Perfluorocarbon gas insufflation

A subject is confined in a closed environment at an elevated pressure through which perfluorochemical fluid containing dissolved oxygen is circulated to treat disease or injury.

Perflurochemical treatment process and apparatus

An open-circuit liquid ventilation system includes a reservoir containing a breathable liquid, a patient interface receiving breathable liquid from the reservoir, a pump directing breathable liquid from the reservoir to the patient, a controller for the pump, and a tank for storing used breathable liquid. The system may be passive regarding expired liquid. Alternatively, the system may be active and include a bypass line connected to the pump such that used breathable liquid is drawn from the patient. The patient interface may be adapted to interface a gas ventilation system to facilitate a rapid conversion from gas to liquid ventilation. The system may include sensors monitoring pressure and volume parameters and may include an output displaying information including schematics and real time tracings regarding a ventilation procedure.

Open-circuit liquid ventilator

The present invention includes a transient method of delivering a biological agent in a breathable liquid to a lung of a patient. The present invention includes a steady state method of delivering a biological agent in a breathable liquid to a lung of a patient. The steps of both the transient delivery method and the steady state delivery method can be controlled by a servo-control unit. A supplementary biological agent delivery step can be performed in both the transient method of delivering a biological agent and the steady state method of delivering a biological agent.

Process for transient and steady state delivery of biological agents to the lung via breathable liquids

A thoracic stabilizer for limiting anterior chest wall collapse includes a platform supporting a patient and a pair of lateral supports contacting opposite sides of the patient's chest wall and applying force to limit collapse of the chest wall. The force applied by the lateral supports is varied depending on the force applied to the platform by the patient. The stabilizer includes a retractometer measuring the collapse of the chest wall. According to one embodiment, the stabilizer includes a controller that varies the force applied to the chest wall in closed-loop fashion based on the chest wall collapse measured by the retractometer using an algorithm of the controller. According to one embodiment, the stabilizer includes motors moving the lateral supports. According to another embodiment, the stabilizer includes a hydraulic system and the lateral supports include expandable fluid-filled members.

Thoracic stabilizer

The dispenser includes an enclosure for holding a plurality of paper rolls in stacked, substantially vertical relation. The front wall of the enclosure has an opening through which a paper roll may move to exit the enclosure. A tray is provided for retaining a paper roll as it moves through the exit opening. A section of the rear wall is inclined to guide a paper roll through the exit opening and into the retaining tray. A removable divider is provided to convert the dispenser for use with different size paper rolls. Brackets for rotatably mount a paper roll extend from the bottom of the enclosure for dispensing individual sheets. Removable decorative panels are provided for mounting proximate the front and side walls. The dispenser may be supported on a horizontal surface by the bottom, suspended from a vertical surface or hung from a door. Openings in the walls permit observation of the number of papers rolls remaining in the enclosure. In one embodiment, the front wall is provided with slots for removably mounting photographs.

Paper roll dispenser with roll retaining tray

Paper roll dispenser

Methods of delivering a therapeutic or diagnostic agent in a perfluorochemical liquid carrier are provided. In preferred embodiments, the disclosed methods use compositions in the form of an emulsion or a dispersion for delivery of a biological agent to the pulmonary air passages.

Growing community of inventors

Philadelphia, PA, United States of America

Marla R Wolfson