Dsm IP Assets B.v.

Novozymes A/s

Roche Vitamins Inc.

Dsm Nutritional Products Inc.

Novozymes Als

Markus Wyss

Luis Pasamontes

Adolphus Van Loon

Dirk Kostrewa

Andrea Tomschy

Kurt Vogel

Martin Lehmann

Allan Svendsen

Renyuan Bai

S&oslash;ren Flensted Lassen

Heinrich Bachmann

Roland Brugger

Arno Martin Friedlein

Gabriele Margarethe Wirtz

Wolf-Dietrich Woggon

Adrian Wyss

Soren Flensted Lassen

Nigel John Mouncey

Rual Lopez-Ulibarri

Markus Huembelin

Sybille Ebert

Hans-Peter Hohnmann

Martin Lehman

The present invention relates to modified mevalonate kinases that are less sensitive to feedback inhibition, and to polynucleotides encoding them. The invention further pertains to vectors comprising these polynucleotides and host cells containing such vectors. The invention provides a process for producing the modified enzyme and for producing isoprenoid compounds using the modified enzymes.

Modified mevalonate kinase with reduced feedback inhibition

The present invention relates to modified GTP cyclohydrolase II enzymes that display increased specific activity, and to polynucleotides encoding them. The invention further pertains to vectors comprising these polynucleotides and host cells containing such vectors. The invention provides a method for producing the modified enzyme and a method for producing riboflavin, a riboflavin precursor, FMN, FAD, or a derivative thereof.

Mutant GTP cyclohydrolase II enzymes

The present invention relates to modified mevalonate kinases that are less sensitive to feedback inhibition, and to polynucleotides encoding them. The invention further pertains to vectors comprising these polynucleotides and host cells containing such vectors. The invention provides a method for producing the modified enzyme and a method for producing isoprenoid compounds.

Feedback-resistant mevalonate kinases

The present invention relates to phytase variants, their preparation and uses, which phytase variants, when aligned according to FIG., are amended as compared to a model phytase in at least one of a number of positions. Preferred model phytases are basidiomycete and ascomycete phytases, such asphytase andphytases. Preferred phytase variants exhibits amended activity characteristics, such as improved specific activity and/or improved thermostability.

Phytase variants

A process for the production of a modified phytase with a desired property improved over the property of the corresponding unmodified phytase is disclosed, as well as modified phytases, polynucleotides encoding modified phytases, and animal feed including modified phytases.

Modified phytases

Nucleic acid sequences coding for a protein having &#x3b2;,&#x3b2;-carotene 15,15'-monooxygenase activity and their uses in diagnostics, the synthesis of vitamin A and methods for the introduction of the &#x3b2;,&#x3b2;-carotene 15,15&#x2032;-monooxygenase cDNA into host cells are disclosed.

&#x3b2;, &#x3b2;-carotene 15, 15'-monooxygenases, nucleic acid sequences coding therefor and their use

Nucleic acid sequences coding for a protein having &bgr;,&bgr;-carotene 15,15&prime; enzyme activity and their uses in diagnostics, the synthesis of vitamin A and methods for the introduction of the &bgr;,&bgr;-carotene 15,15&prime; enzyme cDNA into host cells are disclosed.

B, B-carotene 15, 15&prime;-dioxygenases, nucleic acid sequences coding therefor and their use

The present invention relates to phytase variants, their preparation and uses, which phytase variants, when aligned according to FIG. are amended as compared to a model phytase in at least one of a number of positions. Preferred model phytases are basidiomycete and ascomycete phytases, such as Peniophora phytase and Aspergillus phytases. Preferred phytase variants exhibits amended activity characteristics, such as improved specific activity and/or improved thermostability.

Phytase variants, their preparation and uses, which phytase variants, when aligned according to FIG. , are amended as compared to a model phytase in at least one of a number of positions. Preferred model phytases are basidiomycete and ascomycete phytases, such as Peniophora phytase and Aspergillus phytases. Preferred phytase variants exhibits amended activity characteristics, such as improved specific activity and/or improved thermostability.

Phytase varinats

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Liestal, Switzerland

Markus Wyss