Abbvie Biotechnology Ltd

Abbvie Inc.

Abb Vie Deutschland Gmbh & Co. Kg

Markus Tschoepe

Wolfgang Fraunhofer

Annika Bartl

Hans-Juergen Krause

Katharina Kaleta

Tong Zhu

Susan K Paulson

Carsten Weber

Laura Redden

Martin Gastens

Alexander Feick

Hans-juergen Krause

Michael Neu

Vineet Kumar

The invention provides an aqueous formulation comprising water and a protein, and methods of making the same. The aqueous formulation of the invention may be a high protein formulation and/or may have low levels of conductity resulting from the low levels of ionic excipients. Also included in the invention are formulations comprising water and proteins having low osmolality.

Protein formulations and methods of making same

The invention provides an aqueous formulation comprising water and a protein, and methods of making the same. The aqueous formulation of the invention may be a high protein formulation and/or may have low levels of conductivity resulting from the low levels of ionic excipients. Also included in the invention are formulations comprising water and proteins having low osmolality.

Anti-TNF antibody formulations

The invention provides a liquid aqueous pharmaceutical formulation comprising a human anti-TNFa antibody, or antigen-binding portion thereof, which reduces pain associated with injection in a subject by at least about 50% when compared to injecting an otherwise identical formulation comprising at least one salt and/or at least one buffer. The invention also provides a liquid aqueous pharmaceutical formulation comprising a human anti-TNFa antibody, or antigen-binding portion thereof, having increased bioavailability upon subcutaneous administration into a subject. The formulation may comprise a therapeutic protein, such as a human anti-TNF-alpha antibody, or an antigen-binding portion thereof, or a biosimilar thereof.

High concentration anti-TNF&#x3b1; antibody liquid formulations

Antibody formulations and methods of making same

Growing community of inventors

Hessheim, Germany

Markus Tschoepe