Technische Universitat Munchen

Markus Schwaiger

Horst Kessler

Martina Anton

Norman Koglin

Oliver Demmer

Hans Jürgen Wester

Burkhardt Laufer

Provided herein are compounds or conjugates useful for diagnostic imaging and/or therapeutic purposes. Each compound or conjugate comprises a ligand for the chemokine receptor CXCR4 and a detectable label. The ligand has a binding affinity for the CXCR4 receptor, measured as ICin the presence ofI-CPCR4, of 250 nM or lower, and the ligand comprises a cyclic oligopeptide moiety having the motif B-Arg or B-(Me)Arg within the cyclic moiety, wherein B is a basic amino acid, a derivative thereof, or phenylalanine, provided that the motif is B-Arg when B is a N-methyl derivative of a basic amino acid.

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Munich, Germany

Markus Schwaiger