University of Zürich

Markus Rudin

Jan Grimm

Roger Nitsch

Marlen Knobloch

Felicitas Kranz

Katerina Dikaiou

Thomas Müggler

Florian Stuker

Christof Baltes

Uwe Konietzko

A dual modality imaging apparatus, comprising a magnetic resonance imaging (=MRI) system and a fluorescence molecular tomography (=FMT) system, for investigating a sample () located at a sample position (), wherein the MRI system comprises a magnet () with a room temperature bore (), with the sample position () located within the bore (), and wherein the FMT system comprises means for directing a light beam () towards the sample position (), and a position-sensitive detector () for collecting fluorescence light from the sample (), is characterized in that the position-sensitive detector () is located within the bore (), wherein at least part of the sample () is imaged onto the position-sensitive detector (), and that the means for directing the light beam () comprise a focusing device for focusing the light beam () into a focal spot () on the sample (), and a scanning device for scanning the focal spot () on the sample (). The apparatus is simple in design and versatile in application, and in particular imposes less limitations on the maximum number of source/detector pairs during FMT imaging, thus allowing a better FMT image resolution.

Optical MRI device

Provided is a novel APP (amyloid precursor protein) transgenic non-human animal modeling in vivo the pathophysiological effects and effects on cognitive behavior of early intraneuronal and extracellular brain parenchymal amyloid-&#x3b2; (A&#x3b2;) deposition and cerebral amyloid angiopathy associated with brain microhemorrhages and reduced vasoreactivity and blood flow. Furthermore, methods of screening for therapeutic or diagnostic agents useful in the treatment or diagnosis of Alzheimer's disease, in particular for improving blood flow to the brain are provided as well as the corresponding therapeutic methods.

Transgenic animal model for alzheimer's disease

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Eglisau, Switzerland

Markus Rudin