Merz Pharma Gmbh & Co Kgaa

Markus-Rene Gold

Aigars Jirgensons

Valerjans Kauss

Herbert Koller

Michael Pyerin

The present invention pertains to process for the amidation of a substituted 1-bromo-adamantane comprising a step (0) of reacting a substituted adamantane with an excess of bromine to obtain a 1-bromo-adamantane and a step (i) of reacting said substituted 1-bromo-adamantane with an amide, wherein the substituted 1-bromo-adamantane is used in the form of a mixture comprising bromine as obtained in step (0), wherein in step (0) a bromine: substituted adamantane molar ratio of from [2.5:1] to less than [5:1] is employed.

Process for manufacturing adamantane derivatives with high yield

Method of preparing 1-amino-1,3,3,5,5-pentamethylcyclohexane or a pharmaceutically acceptable salt thereof (Neramexane), comprising step (iv):

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Karlstadt, Germany

Markus-Rene Gold