Basf Aktiengesellschaft

Basf Se Corporation

Evonik Degussa Gmbh

Basf Corporation

Basf Aktiencesellschaft

Paik Kwang Industrial Co., Ltd.

Markus Pompejus

Oskar Zelder

Hartwig Schröder

Gregor Haberhauer

Burkhard Kröger

Corinna Klopprogge

Holger Hartmann

Qingzhao Wang

Zheyuan Guo

Shakir Siraj Ratani

Maria Angeles Santos Garcia

Jose Luis Revuelta Doval

Harald Seulberger

Hartwig Schr&ouml;der

Stefan Haefner

Stephan Freyer

Hartwig Schroeder

Markus Lohscheidt

Matthias Boy

Corrinna Klopprogge

Burkhard Kr&ouml;ger

Alberto Jimenez

Hans Wolfgang Höffken

Hans Wolfgang H&ouml;ffken

Hyung-Joon Kim

Heung-Shick Lee

Jun-Won Kim

Byung-Joon Hwang

Heung Shick-Lee

Hartwig SCHRÖDER

The present invention is concerned with microorganisms or fragments thereof as sensorically neutral oral care agents, particularly for prevention of dental calculus, as anti-caries agents and/or anti-oral malodor agents. The invention is furthermore concerned with compositions comprising microorganisms or fragments thereof for reducing. Such compositions can be used in oral care compositions, e.g. for caries prophylaxis, or for prophylaxis of dental calculus or oral malodor. They may also or instead be used for prevention or treatment of oral malodor. As the microorganisms and fragments thereof according to the present invention have a very low, unobtrusive smell and taste, they are particularly suited as sensorically neutral agents for preventment of dental calculus, caries, oral biofilm formation and/or for prevention or treatment of oral malodor. The microorganisms and fragments thereof, and also compositions comprising such microorganisms and fragments, can thus advantageously be used in food and feed compositions, particularly in pet foods. Furthermore, the invention is concerned with methods of preparing such microorganisms, fragments, compositions, foods and feeds.

Oral health improving compositions

The present invention relates to a recombinant nucleic acid molecule, a recombinant microorganism, to a method for producing alanine and to the use of the recombinant nucleic acid molecule or the recombinant microorganism for the fermentative production of alanine.

Recombinant microorganism for improved production of fine chemicals

Recombinant microorganism for improved production of fine chemicals The present invention relates to a recombinant nucleic acid molecule, a recombinant micro-organism, to a method for producing alanine and to the use of the recombinant nucleic acid molecule or the recombinant microorganism for the fermentative production of alanine.

The invention pertains to the field of reaction systems generating malodor, particularly from constituents of human sweat. Specifically, the invention pertains to proteins for generating malodors, substrates for generating such malodor, inhibitors of such malodor generation and test and screening systems for measuring their malodor inhibition efficacy and finding substances previously not known to inhibit malodor generation. Thus, the invention also pertains to the field of deodorants.

Malodour standards and inhibitors

The invention relates to a process for the production of at least one microbial metabolite having at least 3 carbon atoms or at least 2 carbon atoms and at least 1 nitrogen atom by means of sugar-based microbial fermentation, comprising:

Fermentative production of fine chemicals

A process for the fermentative production of at least one organic compound having at least 3 C atoms or having at least 2 C atoms and at least one 1 N atom, comprising the following steps:

Fermentative production of organic compounds

Isolated nucleic acid molecules, designated MR nucleic acid molecules, which encode novel MR proteins fromare described which are involved in biosynthesis of a fine chemical, e.g., methionine biosynthesis. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MR nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides methods of producing methionine from microorganisms, e.g.,, which involve culturing recombinant microorganisms which overexpress or underexpress at least one MR molecule of the invention under conditions such that methionine is produced. Also featured are methods of producing a fine chemical, e.g., methionine, which involve culturing recombinant microorganisms having selected MR genes deleted or mutated under conditions such that the fine chemical, e.g., methionine, is produced.

Method for producing methionine using a microorganism with reduced expression activity of a negative regulator of methionine biosynthesis

Isolated nucleic acid molecules, which encode novel metabolic regulatory proteins fromare described. These nucleic acid molecules are involved in the biosynthesis of a fine chemical, e.g., methionine biosynthesis. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing metabolic regulatory nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides methods of producing methionine from microorganisms, e.g.,, which involve culturing recombinant microorganisms which overexpress or underexpress at least one metabolic regulatory molecule of the invention under conditions such that methionine is produced. Also featured are methods of producing a fine chemical, e.g., methionine, which involve culturing recombinant microorganisms having selected metabolic regulatory genes deleted or mutated under conditions such that the fine chemical, e.g., methionine, is produced.

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Isolated nucleic acid molecules, designated MP nucleic acid molecules, which encode novel MP proteins fromare described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated MP proteins, mutated MP proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound frombased on genetic engineering of MP genes in this organism.

Isolated nucleic acid molecules, designated PTS nucleic acid molecules, which encode novel PTS proteins fromare described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PTS nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated PTS proteins, mutated PTS proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound frombased on genetic engineering of PTS genes in this organism.

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Freinsheim, Germany

Markus Pompejus