Upm-kymmene Corporation

Upm Specialty Papers Oy

Upm-kymmeme Corporation

Infinited Fiber Company Oy

Markus Nuopponen

Isko Kajanto

Juha Tamper

Lauri Paasonen

Kari Luukko

Antti Laukkanen

Tapani Vuorinen

Marjo Yliperttula

Arto Merivaara

Anne Meriluoto

Taisto Tienvieri

Janne Laine

Jan-Erik Teirfolk

Harri Jukarainen

Tero Satomaa

Timo Pääkkönen

Jaakko Pere

Martina Lille

Monika Österberg

Petter Somersalo

Timo Laaksonen

Heikki Joensuu

Heli Paukkonen

Vili-Veli Auvinen

Tiina Hakkarainen

Elle Koivunotko

Raili Koivuniemi

Piia-Riitta Karhemo

Sami Valkonen

Outi Monni

Harri Kosonen

Arto Olavi Urtti

Jari Helin

Anne Mäkelä

Olli Ikkala

Sami Saarela

Mikko Rissanen

Mika Kosonen

Patrick Laurén

Eino Sivonen

Kyösti Valta

Jouni Paltakari

Tarja Sinkko

Timo Koskinen

Pentti Pirkonen

Sakari Siren

Jani Mäkelä

Helinä Hartikainen

Mikael Skurnik

Tuula Heinonen

Päivi Tammela

Huang Xiang

Tero Ojala

Yanxin Liu

Jukka Rissanen

Lindsay Davies

Teija Jokila

Saara Laitinen

Kalle Manninen

Ossi Korhonen

Jacopo Zini

Haiqiu Song

Erkki Malanin

Stella Rovio

Arto Urtti

Thaddeus Maloney

Sara Ceccherini

Marika Mannerström

Tiina Joki

Laura Ylä-Outinen

Annikki Vehniäinen

Jane Spencer-Fry

Hannu Mursunen

Patrick Laurën

Lisa Chinello

Lauri Kuutti

Pegah Khanjani

Giulia Scapin

Andreas Walther

Kari Hillebrand

Susanna Narkilahti

Raili Ponni

Tarja Toimela

Tomas Bjoerkqvist

Salla Venäläinen

Helmer Gustafsson

Annikki Vehniaeinen

Nicolò Curzio

Polina Ilina

Sheetal Patpatia

Karen Coopman

Saija Kiljunen

Yulong Wang

Olli Aitio

Tomas Björkqvist

Antti Fredrikson

Taru Päiväläinen

Elias Veijola

A method for freeze-drying a hydrogel composition is disclosed, the method comprising providing the hydrogel composition, wherein the hydrogel composition comprises cellulose nanofibrils and/or cellulose nanocrystals, at least one saccharide, at least one amino acid, and biologics; and freeze-drying the hydrogel composition, thereby obtaining a freeze-dried hydrogel composition.

Method for freeze-drying a hydrogel composition and a freeze-dried hydrogel composition

The present disclosure relates to a method for controlling freeze-drying of a hydrogel wherein the method comprises adjusting the residual water content of the freeze-dried hydrogel, and to a freeze-dried hydrogel composition comprising nanoscale cellulose and a at least one biomolecule selected from an oligosaccharide or a disaccharide. The present disclosure further concerns the use of the freeze-dried hydrogel composition for cell culturing, a cell culturing scaffold as well as a process for manufacturing a reconstituted hydrogel.

Controlling freeze-drying of a hydrogel

A cell culture plate includes one or more cell culture well(s) including at least one barrier for dividing the well into at least two compartments, wherein the barrier includes nanofibrillar cellulose hydrogel, and a method for the preparation thereof. A method for detecting a substance is also disclosed.

Cell culture plate, method for preparing thereof and method for detecting a substance

The present invention is related to methods and materials for culturing expanding cells in a three-dimensional culture. The material comprises plant-derived anionic nanofibrillar cellulose, wherein the anionic nanofibrillar cellulose is in a form of hydrogel. The invention also provides methods for producing materials and compositions comprising plant-derived anionic nanofibrillar cellulose.

Supportive nanofibrillar cellulose scaffold for expanding cells

The present application provides a method for preparing nanofibrillar cellulose product, the method comprising providing nanofibrillar cellulose, providing multivalent cations, contacting the nanofibrillar cellulose with the multivalent cations, and allowing reacting for a period of time to obtain cross-linked nanofibrillar cellulose product. The present application also provides a nanofibrillar cellulose product comprising nanofibrillar cellulose and multivalent cations, wherein the nanofibrillar cellulose is crosslinked by the multivalent cations.

Nanofibrillar cellulose product and a method for manufacturing thereof

The present disclosure provides a method for freeze-drying cells in a hydrogel comprising nanofibrillar cellulose, the method comprising providing a hydrogel comprising nanofibrillar cellulose, providing cells, combining the cells and the hydrogel comprising nanofibrillar cellulose to form a cell system, and freeze drying the cell system to obtain dried cells in a hydrogel comprising nanofibrillar cellulose. The present disclosure also provides a freeze-dried hydrogel comprising nanofibrillar cellulose and cells.

Method for freeze-drying cells in a hydrogel comprising nanofibrillar cellulose and freeze-dried cells in an aerogel comprising nanofibrillar cellulose

The present application relates to a method for preparing a medical product, the method comprising providing an aqueous dispersion of nanofibrillar cellulose, providing a nonwoven fabric, immersing the nonwoven fabric in the aqueous dispersion of nanofibrillar cellulose to form a coating on the nonwoven fabric, passing the immersed nonwoven fabric through a prefined gap to define the thickness of the coating on the immersed nonwoven fabric without pressing, and dewatering the immersed nonwoven fabric, to obtain the medical product. The present application also relates to a medical product comprising a supporting layer and an absorbent layer, wherein the supporting layer comprises a nonwoven fabric, and the absorbent layer comprises unpressed nanofibrillar cellulose having an average fibril diameter of 200 nm or less, wherein the absorbent layer is coating the supporting layer.

Medical product and method for preparing thereof

An injectable pharmaceutical formulation includes nanofibrillar cellulose hydrogel wherein the content of nanofibrillar cellulose in the pharmaceutical formulation is the range of 1-8% (w/w), and pharmaceutical compound. The injectable pharmaceutical formulation can provide a sustained release of a pharmaceutical compound in a subject. Use of nanofibrillar cellulose for preparing the injectable pharmaceutical formulation is also disclosed.

Injectable pharmaceutical formulation

The present application relates to a method for preparing a pharmaceutical composition, the method comprising providing pharmaceutical compound having a solubility in water of 1 mg/ml or less at 25&#xb0; C. in a solvent enabling solubilizing the pharmaceutical compound at least partly into the solvent, providing an aqueous dispersion of nanostructured cellulose, and combining the pharmaceutical compound with the aqueous dispersion of nanostructured cellulose in an anti-solvent process to provide nanosized pharmaceutical particles having an average diameter of 50 nm or less, to provide a pharmaceutical composition. The present application also provides pharmaceutical composition, and use of the pharmaceutical composition.

Method for preparing pharmaceutical composition and pharmaceutical composition

A composition or matrix comprising a bacteriophage and nanofibrillar cellulose or a derivative thereof in a wet or dry state is disclosed.

Composition or matrix for storage of bacteriophages comprising nanofibrillar cellulose

The present application provides a method for preparing a medical product for covering tissue, the method comprising providing nanofibrillar cellulose, providing a bioactive molecule, and covalently bonding the bioactive molecule to the nanofibrillar cellulose. The present application also provides a medical product for covering tissue comprising a bioactive molecule covalently bound to nanofibrillar cellulose.

Medical product comprising a bioactive molecule immobilized to nanofibrillar cellulose, and a method for preparing thereof

The present application relates to a medical hydrogel comprising nanofibrillar cellulose, wherein the hydrogel has a viscosity in the range of 2500-9000 Pa&#xb7;s and a water retention value in the range of 30-100 g/g. The present application also relates to a method for preparing the medical hydrogel The present application relates to the medical hydrogel for use for treating wounds.

Medical hydrogel

The present disclosure provides a cell system comprising eukaryotic cells in a hydrogel comprising nanofibrillar cellulose in cell storage medium at a temperature in the range of 0-25&#xb0; C. The present disclosure also provides a method for storing eukaryotic cells, the method comprising providing eukaryotic cells, providing nanofibrillar cellulose, combining the cells and the nanofibrillar cellulose to form the cell system, and storing the cell system at a temperature in the range of 0-25&#xb0; C.

Cell system and method for storing cells

In a method for producing nanofibrillar cellulose, cellulose based fibre material, in which internal bonds in cellulose fibres have been weakened by 5 preliminary modification of cellulose, is subjected to disintegration treatment in form of pulp comprising fibres and liquid. The fibre material is supplied at a consistency higher than 10 wt-%, preferably at least 15 wt-%, to a disintegration treatment where fibrils are detached from the fibre material by joint effect of repeated impacts to the fibre material by fast moving 10 successive elements and the weakened internal bonds of the cellulose fibres. The nanofibrillar cellulose is withdrawn from the disintegration treatment at dry matter which is equal or higher than the consistency of the fibre material.

Method for producing nanofibrillar cellulose and nanofibrillar cellulose product

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Helsinki, Finland

Markus Nuopponen