Gambro Lundia Ab

Schaeffler Technologies Ag & Co .Kg

Hoffmann-La Roche Inc.

F. Hoffmann-La Roche Ag

Markus Neubauer

Bernd Krause

Reinhold Deppisch

Joachim Loercher

Patrick Baer

Juergen Bereiter-Hahn

David Luttropp

Helmut Geiger

Tomas Smetana

Darius Dlugai

Carina Zweigart

Stephan Neuschaefer-Rube

Michael Pausch

Stefan Glück

Jan Matysik

Ruth Dietrich

Frank Benkert

Andrea Schnell

Sergej Mensch

Christian Schmitt

Tobias Killian

Boris Djakovic

Doris Deppisch

Kathrin Hutzel

Sylvia Koch

Reinhold (deceased) Deppisch

Jürgen Bereiter-Hahn

Alexander Herrlein

Jörg Schuh

Stefan Gluck

The invention relates to a membrane which can be used for cultivating adherent or suspension cells, in particular adherent cells, wherein said membrane allows for the adhesion and proliferation of the cells due to the irradiation of the wet or dry membrane with gamma- or beta-rays or an electron beam in a dose of from 12.5 to 175 kGy in the presence of oxygen. The resulting membrane may be used without any pre-treatment with surface-modifying substances. The invention further relates to a method for preparing said irradiated membrane which can be used for the cultivation of cells, in particular adherent cells, and to methods of using such a membrane for the cultivation of cells, in particular adherent cells.

Irradiated membrane for cell expansion

A membrane for cultivating adherent or suspension cells, in particular adherent cells. The membrane permits adhesion and proliferation of the cells due to the irradiation of the wet or dry membrane with gamma or beta rays or an electron beam in a dose of from 12.5 to 175 kGy in the presence of oxygen. The resulting membrane may be used without any pre-treatment with surface-modifying substances. A method for preparing such an irradiated membrane for cultivating adherent or suspension cells. Methods of using such a membrane for cultivating adherent or suspension cells.

Herein is reported a method for the recombinant production of a polypeptide in a eukaryotic cell comprising the steps of (i) cultivating a eukaryotic cell comprising a nucleic acid encoding the polypeptide in a cultivation medium comprising a compound selected from the group consisting of trans-2-methyl 2-pentenoic acid, the broad-spectrum HDAC inhibitor Quisinostat, and the subtype-specific HDAC inhibitor Romidepsin, and (ii) recovering the polypeptide from the cell or the cultivation medium and thereby producing the polypeptide in a eukaryotic cell.

Recombinant production method

A hollow machine element for transmitting a force and/or a torque is provided. The hollow machine element forms a component of an assembly for measuring the acting force and/or torque by using inverse magnetostrictive effect. The hollow machine element extends along an axis and has a cavity that extends along the axis. The machine element includes at least one magnetization region for magnetization, and which includes a magnetostrictive material. A magnetic field measurable via the assembly can be caused by the magnetization and by the force and/or by the torque. The magnetization region is directed toward the cavity and has an axially central segment, in which the magnetization region is arranged at a radial distance from a ferromagnetic region of the machine element to define a gap therebetween. The gap may be empty or filled with insulation, to provide magnetic insulation.

Hollow machine element and assembly for measuring a force or a torque

A device for culturing, storing and expanding adherent renal cells. The device permits the adhesion and proliferation of the cells and the surface characteristics of the membrane material used in said device further permit the cellular matrix components (EMC). A method for expanding adherent renal cells and methods of using particular membranes for culturing, storing and expanding adherent renal cells. The membranes comprise a copolymer of acrylonitrile and sodium methallyl sulfonate as well as polyethylenimine.

Device for renal cell expansion

A bottom bracket unit including a bottom bracket axle (), at least one bearing () that receives the bottom bracket axle () in a rotatable manner, and an optical detection unit (), by which a rotational speed of the bottom bracket axle () can be detected. The optical detection unit () measures at least one signaling device () that is rotationally fixed to the bottom bracket axle (). The aim of the invention is to provide a bottom bracket unit that can also detect the rotational direction of the bottom bracket axle in addition to the rotational speed of the axle. This is achieved in that the optical detection unit () has two optical sensors (), with one of these sensors () providing a signal that is phase-shifted with respect to the other sensor () having a fixed phase difference, in particular with a phase difference of 90&#xb0;.

Bottom bracket unit for a bicycle

A bioartificial kidney equivalent and a process for producing the bioartificial kidney equivalent. The hybrid bioartificial kidney comprises human proximal and distal renal tubule cells grown on particular synthetic membranes.

Hybrid bioartificial kidney

A membrane which can be used for cultivating cells, in particular adherent cells. The membrane permits the adhesion and proliferation of the cells based on its specific composition comprising polyurethane. The resulting surface characteristics further permit the membrane to be used without any pre-treatment with surface modifying substances. A method for preparing a membrane which can be used for cultivating cells, in particular adherent cells. Methods of using the membrane for cultivating cells, in particular adherent cells.

Membrane for cell expansion

Growing community of inventors

Balingen, Germany

Markus Neubauer