Amgen Research (Munich) Gmbh

Amgen Inc.

Immatics Biotechnologies Gmbh

Universiteit Gent

Vib Vzw

Amgen Research Gmbh

Markus Muenz

Tobias Raum

Peter Kufer

Patrick Hoffmann

Doris Rau

Ines Herrmann

Benno Rattel

Cornelius Pompe

Pamela Bogner

Ian Nevin Foltz

Walter C Fiers

Derek Evan Piper

Andreas Wolf

Elisabeth Nahrwold

Christoph Dahlhoff

Xavier Saelens

Ralf Lutterbuese

Jochen Pendzialek

Johannes Brozy

Matthias Friedrich

Julie Bailis

Jonas Anlahr

Alexander Sternjak

Franziska Bott

Igor D'angelo

Kristin Tarbell

Heiko Schuster

Susmith Mukund

Claudia Bluemel

Lars Gaedtke

Weihsu Claire Chen

Kenny Roose

Majk Kvesic

The present invention relates to antibody constructs comprising a domain which binds to a MAGEB2 peptide complexed with an HLA and optionally, another domain which binds to CD3. Moreover, the invention provides polynucleotides encoding the antibody constructs, vectors comprising said polynucleotides and host cells transformed or transfected with said polynucleotides or vectors. Furthermore, the invention provides processes for producing the antibody constructs of the invention, medical uses of said antibody constructs, and kits comprising said antibody constructs.

MAGEB2 binding constructs

The present invention relates to a bispecific antibody construct comprising a first binding domain which binds to human EGFRVIII on the surface of a target cell and a second binding domain which binds to human CD3 on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.

Nucleic acids encoding anitbody constructs binding EGFR VIII and CD3

Method for treating glioblastoma or glioma with antibody constructs for EGFRVIII and CD3

Antibody constructs for EGFRVIII and CD3

The present invention relates to an antibody construct comprising a first human binding domain specific for the extracellular part of the influenza envelope protein M2 (M2e) and a second domain specific for CD3. Moreover, the invention provides a nucleic acid molecule encoding the antibody construct, a vector comprising said nucleic acid molecule and a host cell transformed or transfected with said nucleic acid molecule or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a pharmaceutical composition comprising said antibody construct, a medical use/method of treatment relating to said antibody construct, and a kit comprising said antibody construct.

Antibody constructs for influenza M2 and CD3

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Munich, Germany

Markus Muenz