Unversität Zürich

Csem Centre Suisse D'electronique Et De Microtechnique Sa

Universit&auml;t Z&uuml;rich

Markus Moser

Carsten Korth

Bruno Oesch

Beat Stierli

Rino Ernst Kunz

Hans Sigrist

J&uuml;rg D&uuml;bendorfer

Peter Streit

Peter Stregt

Hui Gao

The presented invention relates to monoclonal antibodies useful in sensitive and specific immunological assays for the identification of prions in various tissues and body fluids, the production of such monoclonal antibodies by means of immunization of PrPmice by means of a new recombinant fragment of PrP and the use of the antibodies, e.g. for therapeutic and preventive treatments of humans and animals suffering from prion diseases.

Immunological detection of prions

The presented invention relates to monoclonal antibodies useful in sensitive and specific immunological assays for the identification of prions in various tissues and body fluids, the production of such monoclonal antibodies by means of immunization of PrP mice by means of a new recombinant fragment of PrP and the use of the antibodies, e.g. for therapeutic and preventive treatments of humans and animals suffering from prion diseases.

This document describes an optical sensor unit and a procedure for the specific detection and identification of biomolecules at high sensitivity in real fluids and tissue homogenates. High detection limits are reached by the combination of i) label-free integrated optical detection of molecular interactions, ii) the use of specific bioconstituents for sensitive detection and iii) planar optical transducer surfaces appropriately engineered for suppression of non-specific binding, internal referencing and calibration. Applications include the detection of prion proteins and identification of those biomolecules which non-covalently interact with surface immobilized prion proteins and are intrinsically involved in the cause of prion related disease.

Optical sensor unit and procedure for the ultrasensitive detection of chemical or biochemical analytes

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Zurich, Switzerland

Markus Moser