Bruker Biospin Ag

Bruker Switzerland Ag

Other

Bruker Biospin Gmbh

Markus Mayer

Roger Meister

Alexander Krahn

Daniel Guy Baumann

Franco Sestito

Robert Schauwecker

Patrick Wikus

Oskar Schett

David Osen

Armin Purea

Dirk Wilhelm

Beat Grossniklaus

Martin Woodtli

Federico Raffa

Daniel Knecht

An NMR spectrometer () with a permanent magnet device () with measurement volume () and bore () for inserting an NMR measurement sample contained in a sample tube (), and with an RF coil () outside a cylindrical temperature control pipe () with a continuous annular air gap () through which temperature control gas can be conducted through a gas inlet (), is characterized in that on the end opposite the gas inlet, a movable holding device () is installed which, in a first operating position, does not touch the sample tube, in a second operating position, holds the sample tube in its measuring position at its outer circumference in a force-fitting and/or form-fitting manner with an axially acting force or static friction F, and, in a third operating position, releases the sample tube for removal, and that in the second operating position F>F−F, where Fis the buoyancy force generated by the dynamic pressure of the temperature control gas flowing onto the sample tube and Fis the weight force of the sample tube. This enables the problems of known arrangements of the type in question with the dynamic pressure caused by the temperature control gas to be avoided.

Holding of NMR measurement samples in a space-restricted NMR spectrometer

A fastening device for releasably fastening a probe () to an NMR magnet (). An insert part () fastens the probe to a retaining system () connected to the magnet. A force-variable connection is established by the insert part with spring elements (). The probe fastens to the insert part with rigid retaining elements (). When closed, a connection without mechanical play exists between the insert part and the retaining elements when the spring elements are under tension. An annular disc-shaped pretensioning element () is arranged between the insert part and the retaining system. By rotating the pretensioning element relative to the insert part, the pretensioning element presses on and pretensions the spring elements. When open, the spring elements and the retaining elements are configured to connect with a mechanical play of 0.5 to 5 mm between the insert part and the retaining elements when the spring elements are pretensioned.

Quick coupling for mounting an NMR probe on a shim system

An NMR rotor comprises a receptacle for inserting a sample container into a homogeneous region of an NMR magnetic field with flux density B, the field vector of which in the homogeneous region extends in the vertical direction along a z-axis. The rotor passes through regions with inhomogeneous magnetic field components and a flux density gradient dB/dz when the sample container is introduced. The rotor includes at least two different materials, one with diamagnetic properties and another with non-diamagnetic properties. The different materials are arranged to be geometrically distributed in the rotor so that the magnetic force on the rotor under the effect of a product t of magnetic flux density B and flux density gradient dB/dz, the magnitude of which exceeds 1400 T/m, either acts in the same direction as the weight force of the rotor or is smaller in magnitude than the weight force of the rotor.

Magnetically compensated NMR rotor

A probe head () of an NMR-MAS assembly has a stator () with an opening () receiving a rotor () which, in a measuring position, rotates at the magic angle to the Bfield. The stator is pivotable between the measuring position and a loading position of the rotor. A detection device () permits external, contactless identification of whether the opening of the stator is fitted with a rotor. The detection device has a light source (), from which light is introduced into a lower end (&#x2033;) of a light guide (). The stator has a first bore (), in which a first light guide stump () is positioned such that, in the loading position of the stator, it produces an optical connection between a rotor inserted in the stator and an upper end (') of the light guide opposite the lower end.

NMR-MAS probe head with pivotable stator

A shim system for influencing and homogenizing the magnetic field of an NMR system includes a coil former (), an extension tube () and a terminal unit (), as well as partial coils () that are mounted on the coil former. Terminal lines () for connecting the partial coils to the terminal unit are initially electrically disconnected from one another between the coil former and the extension tube. A circuit board () with connection lines (), however, is interposed between the disconnected terminal lines. This makes it possible to redesign the shim system in the mechanical construction thereof using simple technical measures and standard components, and without giving rise to significant additional costs. Therefore, production of the partial windings on the coil former can take place in a simplified, economical and automated manner, without requiring an extension tube to be already fitted.

NMR shim system

A fastening system for attaching an NMR probe to an NMR magnet includes a discoid insert and a retention system that is rigidly connected to the magnet and on which the insert can be mounted. A form-fitting, variable-force connection is established between the NMR probe and the retention system using a spring element. The probe attaches to the insert by a plurality of integral, rigid retaining elements that are of an invariable fixed length. The spring element and the retaining elements are designed geometrically such that in a first, opened state the connection between the insert and the retaining elements has a mechanical backlash between 0.5 mm and 5 mm when the spring element is relaxed. In a second, closed state the connection between the insert and the retaining elements has no mechanical backlash when the spring element is under mechanical tension.

Fastening device for an NMR probe having a quick-release fastener

A transport device for transporting an NMR sample to the probe head () of an NMR spectrometer by means of a transport system () is characterized in that the transport device comprises a shuttle () adapted for use with a transport system. The transport system is structured to transport an HR-NMR sample spinner or an NMR MAS rotor (). The shuttle includes a locking device for the NMR MAS rotor, the locking device being formed such that the NMR MAS rotor is released by unlocking the locking device and can be transferred to and received by the NMR MAS probe head. It is therefore possible to rapidly change from NMR spectroscopy of liquids to NMR spectroscopy of solids, and vice versa, simply by exchanging the probe head, without converting the transport system.

Shuttle for an NMR MAS rotor

Temperature control device () for an NMR sample tube (), wherein multiple interleaved, concentric flow channels () for temperature control fluid extending coaxially with respect to a cylindrical interior space () for holding the NMR sample tube are constituted around said interior space (), wherein said temperature control device is constituted such that it is closed toward the interior space in an axial end region () and, an axial end region () at the opposite end thereto, open to the interior space for inserting the NMR sample tube into said interior space (), wherein, in a counter flow region (GB), adjacent flow channels () are interconnected through a fluid passage () at one axial end in such a way that the direction of a fluid flow in the flow channels of the counter flow region is reversed with respect to the corresponding adjacent flow channel in the counter flow region, wherein the outermost flow channel () of the counter flow region has a fluid inlet () at one axial end, and wherein the innermost flow channel () of the counter flow region has a fluid passage () to the interior space at one axial end that faces toward the axial end region that is closed, is characterized in that at least one of the flow channels, in particular, the outermost flow channel () of the temperature control device and/or the next outermost flow channel () of the temperature control device has a fluid outlet () at one axial end, through which at least part (MS) of the temperature-controlling fluid flow that is conveyed along the outermost flow channel () of the temperature control device can escape from the temperature control device without passing through all of the flow channels of the counter-low region. With this invention, temperature control of an NMR sample tube can be ensured with low temperature gradients, while achieving a high temperature control performance.

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Gossau, Switzerland

Markus Mayer