Bayer Aktiengesellschaft

Westfalia Separator Ag

Bayer Animal Health Gmbh

Adverio Pharma Gmbh

Elanco Animal Health Gmbh

Gea Westfalia Separator Gmbh

Markus Longerich

Peter Fey

Ernst-Ulrich Himmen

Jürgen Scholz

Ralf Wischnat

Werner Hoheisel

Ulrich Esser

Mathias Berwe

Guido Becker

Michal Sowa

Anja Ehrig

Juergen Scholz

Rajesh Sharma

Heike Neumann

Anshuman V Patwardhan

Elisabeth Kersten

Joerg Brockob

Joerg Wirths

Detlef Freyer

Antje Dietzel

Michael Ostendorf

Valentina Paula Conty

Jörg Wirths

The present invention relates to methyl {4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate in the form of a novel active compound product having improved properties, for example in respect of the isolability of the active compound product, the dischargeability of the active compound product after isolation and drying and also conveyability, sieveability and micronizability of the active compound product, and to processes for the production and formulation thereof.

Methyl {4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate active compound product having improved properties, production and formulation thereof

Quinolonecarboxylic esters of the general formula (II) are hydrolyzed to quinolonecarboxylic acids of the general formula (I):  The method comprises the step A): A) reacting compounds of the formula (II) with a mixture comprising acetic acid, sulfuric acid and water In step A), &#x2265;30 to &#x2264;40 mol of acetic acid, &#x2265;0.3 to &#x2264;1 mol of sulfuric acid and &#x2265;0.9 to &#x2264;2.5 mol of water are used per mole of compounds of the formula (II). The method is particularly suitable for the synthesis of the intermediate (I) in the synthesis of pradofloxacin.

Method for the hydrolysis of quinolonecarboxylic esters

The invention relates to a deviation ring for paste comprising an annular rebound wall () for a self-distributing centrifuge (). The invention also relates to a corresponding self-distributing centrifuge (). In the deviation ring, the angle of incidence ? of the tangents of the rebound wall () of the deviation ring (), opposite the distribution slit () of the centrifuge (), in relation to the horizontal, is between 3 and 60&#xb0; over the entire opening width of the distribution slit ().

Deviation ring for a self-distributing centrifuge

Method for separating blood plasma particles from a blood plasma suspension in a self-discharging centrifuge having two or more discharge slits and axially stacked baffle plates, in which the blood plasma particles are separated from the liquid phase by centrifuging and removal of the liquid phase, suctioning off liquid remaining in the drum after separation of the blood plasma particles and discharging the sediment of solid blood plasma particles from the drum by centrifugal force into a collecting container underneath the drum, the drum and the blood plasma sediment being cooled during one or more of the process steps.

Method for the separation of blood plasma particles from a blood plasma suspension

Growing community of inventors

Kö'ln, Germany

Markus Longerich