Aalto University

Politecnico Di Milano

Markus Linder

Robin Ras

Pezhman Mohammadi

Sesilja Aranko

Christopher Jonkergouw

Ekaterina Osmekhina

Kodiah Beyeh

This invention relates to macrocyclic cavity containing compounds and uses thereof in inhibiting a microbial signalling molecule or in reducing the amount of a microbial signalling molecule in a subject. The invention also relates to methods for inhibiting a microbial signalling molecule or for reducing the amount of a microbial signalling molecule in a subject by contacting a macrocyclic cavity-containing compound with said subject.

Method of inhibiting gram-negative bacterial quorum signalling molecules using the macrocycle pillar[5]arene

The present invention is directed to a method for producing a condensed phase of a silk fusion protein, the method comprising the steps of preparing a solution of a silk fusion protein in an aqueous medium and concentrating the silk fusion protein in the aqueous medium, wherein the fusion protein is isolated from a recombinant production host and comprises a silk-like protein sequence and two separate non-silk terminal module sequences, such as cellulose binding modules, SpyCatcher domains, tenth type III module of Fibronectin, gamma-crystallin D, flanking the silk-like protein sequence; wherein the method is performed so that the silk fusion protein is not precipitated and subsequently dissolved to the aqueous medium. The present invention is also directed to using such fusion proteins as adhesives.

Method for producing a condensed adhesive phase of silk fusion proteins

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Aalto, Finland

Markus Linder