Valtion Teknillinen Tutkimuskeskus

Teknologian Tutkimuskeskus Vtt Oy

Teknologian Tutkimuskeskus Vtt

Markus Linder

Merja Penttilä

Tiina Nakari-Setälä

Maria-Regina Kula

Richard Fagerström

Klaus Selber

Folke Tjerneld

Hans Söderlund

Jouni Ahopelto

Eero Mustalahti

Jussi Joensuu

Päivi Laaksonen

Katri Kurppa

Arja Paananen

Michael Lienemann

The present invention relates to a purification and concentration method for proteins and antibodies. Particularly the present invention relates to a continuous surfactant based phase separation method for recovering hydrophobin fusion proteins, and for recovering target molecules, such as antibodies, directly from a liquid by using phase separation and hydrophobin-Protein A fusion technologies.

Concentration and purification of hydrophobins and antibodies with a phase separation method

This document describes graphene-containing platelets and methods of exfoliating graphene from a surface. The method comprises facilitating exfoliation by treatment with proteins. In an embodiment, the proteins adhere to the surface of graphene and then the produced platelets may contain a graphene layer and a protein layer on the surface of the graphene layer. Electronic devices containing such platelets are also described.

Graphene-containing platelets and electronic devices, and method of exfoliating graphene

The present invention relates to isolation and purification of protein in aqueous two-phase systems (ATPS). Specifically, the invention provides processes for partitioning of proteins of interest in ATPS by fusing said proteins to targeting proteins which have the ability of carrying said protein into one of the phases.

Process for partitioning of proteins

The present invention relates to immobilization of fusion proteins to surfaces. According to this invention a fusion polypeptide comprises an adhesion polypeptide fused to a preselected polypeptide. Specifically the method takes advantage of the spontaneous immobilization properties of the adhesion polypeptide part of the fusion protein.

Method for immobilization of polypeptides

The present invention relates to isolation and purification of proteins in aqueous two-phase systems (ATPS). Specifically the invention provides processes for partitioning of proteins of interest in ATPS by fusing said proteins to targeting proteins which have the ability of carrying said protein into one of the phases.

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Helsinki, Finland

Markus Linder