Navigo Proteins Gmbh

Markus Liebscher

Erik Fiedler

Ulrich Haupts

Eva Bosse-Doenecke

Paul Knick

Florian Settele

Mathias Kahl

Julia Hennicke

The invention generally relates to targeted compounds for the site-specific coupling of chemical moieties. The present invention features a targeted compound for the coupling of chemical moieties comprising at least one targeting domain capable of binding a target, and at least one linking moiety of up to 80 amino acids, preferably alanine, proline, and serine, and at least one coupling site consisting of cysteine or a cysteine-rich peptide motif (CXC, CXXC, or CXXXC), and wherein said linking moiety connects the targeting domain and a coupling site and/or wherein a linking moiety connects two coupling sites. The invention further features fusion proteins with ubiquitin muteins (Affilin @) as targeting domain. The invention also relates to the use of the targeted compounds for medical applications, in treatment or diagnosis of diseases.

Targeted compounds for the site-specific coupling of chemical moieties comprising a peptide linker

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Halle/Saale, Germany

Markus Liebscher