University of Iowa Research Foundation

Yale University

Markus Kuehn

Gregory S Hageman

Young H Kwon

Sandeep Saluja

Erin Lavik

James Bertram

John Huang

Biodegradable polymeric microparticle compositions containing one or more active agents, especially those useful for treating or preventing one or more diseases or disorders of the eye, and methods of making and using thereof, are described. In a preferred embodiment, the microparticle compositions contain one or more active agents useful for managing elevated intraocular pressure (IOP) in the eye. Relatively hydrophilic, and preferably carboxylated, polymeric materials such as PLGA are used for a drug such as timolol maleate, which is relatively water soluble, to increase drug loading. Higher molecular weight polymers, as well as the ratio of LA (which has a longer degradation time, up to one to two years) to GA (which has a short degradation time, as short as a few days to a week), are used to provide release over a longer period of time.

Sustained intraocular delivery of drugs from biodegradable polymeric microparticles

Methods and compositions for treating ocular disorders such as retinal detachment and macular degeneration and methods and compositions for prognosing or diagnosing retinal detachment or macular degeneration in a subject are disclosed.

Nucleic acids encoding interphotoreceptor matrix proteins

Growing community of inventors

Amana, IA, United States of America

Markus Kuehn