Gruenenthal Gmbh

Grunenthal Gmbh

Markus Kegel

Wolfgang Hell

Helmut Buschmann

Detlef Heller

Felix Spindler

Hans-Joachim Drexler

Andreas Fischer

Joerg Holenz

Oswald K Zimmer

Michael Gruss

Markus Von Raumer

Stefan Gladow

Hartmut Loebermann

Bernhard Akteries

Joerg Berghausen

Olaf Schaefer

Urs Siegrist

Susan Margaret Paul

Harmut Loebermann

Jorg Holenz

Anita Schnyder

Hans-Joachin Drexler

Olaf SCHÄFER

Compounds of the formula II can be hydrogenated to the corresponding butane derivatives in the presence of homogeneous cataslysts composed of metal salts or complexes containing metals selected from the group consisting of Rh, Ir, and Ru and preferably containing diphosphine ligands, with, in addition, excellent optical yields being achieved when one of Rand Ris not a hydrogen atom and the diphosphine ligand is chiral.

Process for preparing a substituted dimethyl-(3-arylbutyl)amine compound by homogeneous catalysis

A crystalline salt of 3-[2-(dimethylamino)methyl(cyclohex-1-yl)]phenol and hydrogen chloride, preferably in a 1:1 composition, including various crystalline forms of this salt, processes for preparing the various crystalline forms of this salt, pharmaceutical compositions containing the various crystalline forms of this salt, and the use of this salt as a pharmacologically active agent in a pharmaceutical composition to treat or inhibit pain or other disorders or disease states.

HCI polymorphs of 3-((2-(dimethylamino)methyl(cyclohex-1-yl)) phenol

A process for producing 6-dimethylaminomethyl-1-(3-hydroxy- or 3-C-Calkoxyphenyl)-cyclohexane-1,3-diols from 6-dimethylaminomethyl-1-hydroxy-1-(3-hydroxy- or 3-C-Calkoxyphenyl)-cyclohexane-3-ones by catalytic hydrogenation in the presence of heterogeneous or homogeneous catalysts, or by using metal hydrides.

Process for producing 6-dimethylaminomethyl-phenyl-cyclohexane-1,3-diols

Methods for the dehydration of substituted 1-amino-3-aryl-butan-3-ol compounds for the preparation of substituted 3-aryl-butyl-amine compounds.

Process for the preparation of substituted 3-aryl-butylamine compounds

The present invention relates to a process for converting a tertiary OH group of an organic compound into a tertiary Cl group of the organic compound by using a solvent selected from the group comprising toluene, o-xylene, m-xylene, p-xylene and mixtures thereof, and thionyl chloride as the chlorinating agent.

Process for chlorinating tertiary alcohols

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Aachen, Germany

Markus Kegel