Glycom A/s

Markus Jondelius Hederos

Martin Matwiejuk

Pierre Chassagne

Nikolay Khanzhin

Gyula Dekany

Elise Champion

Bruce McConnell

Louise Kristine Vigsnæs

Lars Kröger

Christoph Röhrig

Andreas Schroven

Piroska Kovács-Pénzes

Julien Boutet

Ferenc Horváth

Ioannis Vrasidas

Károly Ágoston

István Bajza

Péter Trinka

Pauline Peltier-Pain

Christian Risinger

Ágnes Ágoston

Benjámin Podányi

Györgyi Osztrovszky

Gergely Pipa

Sándor Demkó

Ignacio Figueroa Pérez

Dóra Molnár-Gábor

László Kalmár

Dóra Molnàr-Gàbor

Niels Banke

Gábor Kádár

The invention relates to a method for selective crystallization of 2'-fucosyllactose (2′-FL) from an aqueous solution comprising 2′-FL and one or more other fucosylated carbohydrates by adding acetic acid to the solution. The aqueous solution is separated from an aqueous culture medium prior to crystallization.

Separation of 2'-FL from a fermentation broth

It is provided i) an amorphous carbohydrate with improved chemical stability and/or physical features, ii) a method for producing an amorphous carbohydrate with improved chemical stability and/or physical features, and iii) a method for improving the chemical stability and/or the physical features of an amorphous carbohydrate.

Amorphous mixture comprising a neutral mono- or oligosaccharide and an acidic non-carbohydrate component

This invention relates to a method for the enzymatic synthesis of oligosaccharides, preferably human milk oligosaccharides (HMOs) The method comprises the enzymatic transfer of a glycosyl moiety and subsequent removal of by-products, such as lactose, by nanofiltration using a membrane comprising an active polyamide layer.

Synthesis of oligosaccharides

The invention relates to crystalline polymorphs of lacto-N-tetraose (LNT) and methods for making the same for use in pharmaceutical compositions, nutritional formulations and food supplements.

Crystalline forms of LNT

The present disclosure relates to synthetic mixtures of certain human milk oligosaccharides and uses thereof. Particular mixtures provided herein include: lacto-N-triose II, lacto-N-neotetraose, para-lacto-N-neohexaose, and, optionally, lactose; and lacto-N-triose II, lacto-N-tetraose, para-lacto-N-hexaose II, and, optionally, lactose. These mixtures are useful in the prevention and treatment of viral and bacterial infections.

Compositions comprising HMOS, their production and use for the prevention and/or treatment of viral and/or bacterial infections

The present invention relates to a method of removing residual organic solvent from crystalline oligosaccharides by the use of water vapour as well as the pharmaceutically and nutritionally suitable crystalline oligosaccharides obtained by said method.

Method for removing residual organic solvent from a crystalline oligosaccharide

The invention relates to a method for obtaining an N-acetylglucosamine containing neutral oligosaccharide from a fermentation broth, wherein said oligosaccharide is produced by culturing a genetically modified microorganism capable of producing said oligosaccharide from an internalized carbohydrate precursor, comprising the steps of: i) ultrafiltration (UF), preferably to separate biomass from the broth, ii) nanofiltration (NF), preferably to concentrate said oligosaccharide in the broth and/or reduce an inorganic salt content of the broth, and iii) treating the broth with an ion exchange resin, preferably to remove charged materials, and/or subjecting the broth to chromatography, preferably to remove hydrophobic impurities.

Separation of oligosaccharides from fermentation broth

The invention relates to separation of disaccharides from tri- or higher oligosaccharides by nanofiltration.

Purification of oligosaccharides

The present invention relates to a method for separating sialylated oligosaccharides from a fermentation broth in which they are produced by a genetically modified microorganism The separation comprises the steps of: i) ultrafiltration; ii) nano-filtration; iii) optionally, activated charcoal treatment; and iv) treatment with strong anion and/or cation exchange resin.

The present invention relates to the isolation and purification of sialylated oligosaccharides from an aqueous medium in which they are produced.

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Trelleborg, Sweden

Markus Jondelius Hederos