Camurus Ab

Camarus Ab

Markus Johansson

Markus Johnsson

Fredrik Tiberg

Fredrik Joabsson

Ian Harwigsson

Krister Thuresson

The present invention relates to pre-formulations comprising low viscosity, non-liquid crystalline, mixtures of: a) at least one neutral diacyl lipid and/or at least one tocopherol; b) at least one phospholipid; c) at least one biocompatible, oxygen containing, low viscosity organic solvent; wherein at least one bioactive agent is dissolved or dispersed in the low viscosity mixture and wherein the pre-formulation forms, or is capable of forming, at least one liquid crystalline phase structure upon contact with an aqueous fluid. The preformulations are suitable for generating parenteral, non-parenteral and topical depot compositions for sustained release of active agents. The invention additionally relates to a method of delivery of an active agent comprising administration of a preformulation of the invention, a method of treatment comprising administration of a preformulation of the invention and the use of a preformulation of the invention in a method for the manufacture of a medicament.

Lipid depot formulations

Liquid depot formulations

The present invention relates to pre-formulations comprising low viscosity, non-liquid crystalline, mixtures of:

Opioid depot formulations

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Lund, Sweden

Markus Johansson