Merck Serono S. A.

Selexis S.a.

Merk Serono S.a.

Markus Imhof

Christine Power

Philippe Chatellard

Nicolas Mermod

Monique Zahn-Zabal

Pierre-Alain Girod

Vincent Dechavanne

George Feger

Nigel Jenkins

Peter Hjelmstrom

Renata Pankiewicz

Gian Battista Bozzato

The invention relates to an expression vector comprising the promoter of the mCMV-IE2 gene, or a functional expression promoting fragment thereof, and/or an enhancer of the mCMV-IE2 gene, or a functional expression enhancing fragment thereof, wherein the expression vector does not contain any complete gene of the mCMV.

Expression vectors comprising the mCMV IE2 promoter

The invention relates to expression vectors comprising a DNA sequence of 146 bp capable of acting as chromatin insulator, to host cells containing such vectors, to a method of producing a desired polypeptide by using vectors containing said sequence and to the use of said DNA sequence.

Minimal DNA sequence acting as a chromatin insulator and its use in protein expression

The invention relates to an expression vector comprising the promoter of the mCMV-IE2 gene, or a functional expression promoting fragment thereof, and/or an enhancer of the mCMV-IE2 gene, or a functional expression enhancing fragment thereof, wherein expression vector does not contain any complete gene of the mCMV.

The present invention relates to compositions and methods for transfecting eukaryotic cells with nucleic acid vectors. In particular, the invention relates to the uses of Matrix Attachment Region (MAR) elements to increase stable and transient transfection efficiency.

Matrix attachment regions and methods for use thereof

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Chexbres, Switzerland

Markus Imhof