Glaxo Group Limited

Convergence Pharmaceuticals Limited

Markus Bergauer

Giuseppe Alvaro

Roberto Profeta

Riccardo Giovannini

Simon Edward Ward

Colin Philip Leslie

Barbara Bertani

Jessica Tibasco

David Amantini

Alessandro Falchi

Domenica Antonia Pizzi

Luigi Piero Stasi

Matteo Biagetti

Giancarlo Merlo

Marilisa Rinaldi

Francesca Bonetti

Antonio Kuok Keong Vong

Steven Mark Bromidge

Agostino Marasco

Daniele Andreotti

Compounds of formula (I), pharmaceutical compositions thereof, and methods for treatment using the same. 

Compounds

The invention provides a compound of formula (I), a solvate, a salt or prodrug thereof, useful in the treatment of diseases and conditions mediated by modulation of use-dependent voltage-gated sodium channels. Methods of treating epilepsy in a mammal are also provided.

Method of treating epilepsy by administering 5-(4{[(2-fluorophenyl)methyl]oxy}phenyl)prolinamide

The invention provides a compound of formula (I), a solvate, a salt or prodrug thereof, useful in the treatment of diseases and conditions mediated by modulation of use-dependent voltage-gated sodium channels. Methods of treating and moderating one or more bipolar disorders in a mammal are also provided.

Methods of treating bipolar disorders

Compounds of formula (I) wherein the variables are defined herein, pharmaceutical compositions thereof and methods for treatment using the same. 

The invention relates to quaternary &#x3b1;-aminocarboxyamide derivatives of formula (I), wherein R, R, R, R, R, R, X, q and n are as defined in claim, for treating diseases and conditions mediated by modulation of voltage-gated sodium channels. 

Disclosed are methods for the preparation of compounds of formula (I): wherein R, m, X, R, n, W, p, Y, Z, R, R, Rand q have the meanings as defined in the description.

Quinoline and quinazoline derivatives having affinity for 5HT1-type receptors

The invention provides a compound of formula (I), pharmaceutical compositions thereof, and methods of treatment using the same. 

Disclosed are methods for use of compounds of formula (I) in combination with other active substances in the treatment of CNS disorders such as depression or anxiety. wherein R, m, X, R, n, W, p, Y, Z, R, R, Rand q have the meanings as defined in the description.

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Verona, Italy

Markus Bergauer