Proteus Digital Health, Inc.

Otsuka Pharmaceutical Company, Limited

Other

University of California

Redwood Microsystems, Inc.

Proteus Biomedical, Inc.

Mark Zdeblick

Timothy Robertson

Hooman Hafezi

George M Savage

Lawrence W Arne

Olivier K Colliou

Andrew S Thompson

Benedict Costello

Aleksandr Pikelny

Yashar Behzadi

Robert C Leichner

Patricia Johnson

William H McAllister

Todd Thompson

Marc Jensen

Cherie Elaine Kushner

Robert Alan Fleming

Jonathan Withrington

Haifeng Li

Nilay D Jani

Zahedeh Hatamkhany

James Hutchison

Angela Strand

Andrew Thompson

Robert Duck

Raymond H Schmidt

Aditya Dua

Jeremy Frank

David O'Reilly

Joseph M Ruggio

Fataneh Omidvar

Jafar Shenasa

Marc S Kreidler

Eric Snyder

Kit Yee Au-Yeung

Veeraperumanallu Muralidharan

Yafei Bi

Kenneth Rowberry

Robert Fleming

Patrick Beaulieu

Robert L White

Alireza Shirvani

Jeffrey Berkman

Arna Ionescu Stoll

Tariq Haniff

William H Mcallister

Cherie Kushner

John S Fitch

James Allen Folta

Albert Karl Henning

Kityee Au-Yeung

Gregory Moon

Dean Allyn Hopkins, Jr

Erika Karplus

Bruce Addis

Robert Leichner

Vladimier Gelfandbein

Leslie Joe Lilly

Dino Lei

Veeraperurnanallu Muralidharan

Benedict J Costello

Nilay Jani

Georgr M Savage

Alexander Pikelny

David O'reilly

An apparatus includes a food product, at least one ingestible device associated with the food product to communicate information and at least one coating material surrounding the at least one ingestible device is disclosed. The ingestible device is associated with an ingestible medication to be ingested in conjunction with the food product. The coating is configured to release the at least one ingestible device upon the occurrence of an event.

Masticable ingestible product and communication system therefor

Methods, systems and compositions that allow for treating a patient according to a patient customized therapeutic regimen are provided. Embodiments of the invention include obtaining dosage administration information from a patient and using the same to tailor a therapeutic regimen for the patient. Embodiments of the invention further include preparing and forwarding to the patient physical pharmaceutical dosages based on the customized therapeutic regimen.

Patient customized therapeutic regimens

A system for tracking a product from origin to destination is disclosed. The system includes a probe that comprises two plates, a power source and a processor. The power source is controlled by the processor to produce an oscillating output at the plates. Using the oscillating voltage, the probe interrogates a device through capacitive coupling. The device includes a control unit, a memory unit, and first and second materials physically associated with the device for communication using capacitive coupling. Information associated with the device is transferred from the device to the probe through capacitive coupling between the first and second materials and the first and second plates, respectively.

System for supply chain management

An apparatus that includes a partial power source including a first material and a second material, the partial power source configured to generate, upon contact with a conducting medium, a potential difference between the first material and the second material to provide power to a control device, and generate, using the first material and the second material, a current flow within the conducting medium, the current flow including information encoded based on a variable conductance between the first material and the second material.

Pharma-informatics system

Apparatuses for use with a pharmaceutically acceptable carrier. The apparatus can include a partial power source, which in turn includes electrodes or materials that are configured to generate an electrical potential upon contacting or being exposed to an ionic solution. The apparatus can further include a circuit electrically or communicatively coupled to the partial power source. The circuit can generate various types of signals, such as RF signals, when powered by the partial power source. The circuit is stably fittable to the pharmaceutically acceptable carrier. The apparatus can further include a barrier, a protective layer, or a membrane that isolates the electrodes or materials from the ionic solution and is configured to be dissolved by the ionic solution.

Controlled activation ingestible identifier

The ingestible event marker data framework provides a uniform, comprehensive framework to enable various functions and utilities related to ingestible event marker data (IEM data). The functions and utilities include data and/or information having an aspect of data derived from, collected by, aggregated by, or otherwise associated with, an ingestion event.

Ingestible event marker data framework

A method may comprise receiving and sampling a signal. The signal may encode a data packet. A slice may be generated and stored comprising a pair of values for each of a selected number of samples of the signal representing a correlation of the signal to reference functions in the receiver. The presence of the data packet may then be detected and the detected packet decoded from the stored slices. The generating and storing slices may be carried out as the received signal is sampled. The sampled values of the signal may be discarded as the slices are generated and stored. The slice representation of the signal can be manipulated to generate filters with flexible bandwidth and center frequency.

Methods, devices and systems for receiving and decoding a signal in the presence of noise using slices and warping

The system of the present invention includes a conductive element, an electronic component, and a partial power source in the form of dissimilar materials. Upon contact with a conducting fluid, a voltage potential is created and the power source is completed, which activates the system. The electronic component controls the conductance between the dissimilar materials to produce a unique current signature. The system can be used in a variety of different applications, including as components of ingestible identifiers, such as may be found in ingestible event markers, e.g., pharma-informatics enabled pharmaceutical compositions.

Communication system with partial power source

Provided is an electronic device having a control device, a driver circuit coupled to the control device. The driver circuit is configured to alter conductance. A partial power source is coupled to the control device and is configured to provide a voltage potential difference to the control device and the driver circuit as a result of the partial power source being in contact with a conductive fluid. The partial power source includes a first material electrically coupled to the control device and a second material electrically coupled to the control device and electrically isolated from the first material. An inductor is coupled to the driver circuit. The driver circuit is configured to develop a current through the inductor. The magnitude of the current developed through the inductor is varied to produce an encoded signal that is remotely detectable by a receiver. Receivers to receive and decode also are disclosed.

Electromagnetic sensing and detection of ingestible event markers

A headwear device for detecting an electrical signal generated by an ingestible event marker is disclosed. The headwear device includes a detection subsystem to receive an electrical signal generated by an ingestible event marker from a detection arrangement. A processing subsystem is coupled to the detection subsystem to decode the electrical signal. A radio subsystem is configured to transmit the decoded electrical signal to a wireless node. A system includes the headwear device and the detection arrangement. A method includes receiving the electrical signal generated by the ingestible event marker at the headwear device, decoding the electrical signal to extract information associated with the ingestible event marker, and transmitting the information to a wireless node.

Headwear device for detection and communication of information received from an ingestible device

A system for administering prescription medications including a composition and a receiver. The composition may include an active agent, an identifier, and a pharmaceutically acceptable carrier. The active agent may include a controlled pharmaceutical. The identifier may include: a partial power source having a first material and a second material configured to generate a voltage in contact with a conductive fluid within a body of a patient, and a signal generation component configured to use at least a portion of the generated voltage to transmit a signal through the body of the patient. The receiver may be positioned near the body of the patient, wherein the receiver is configured to: receive the signal transmitted through the body of the patient, and automatically report the signal for at least one of identification of the controlled pharmaceutical or tracking physical administration of the controlled pharmaceutical to the body of the patient.

Low profile antennas for ingestible devices, such as ingestible event markers, are provided. Aspects of the ingestible devices of the invention include low profile signal transmission antennas configured such that they are flexible or degrade after use, allowing the antenna and attached components to pass easily through the body. Embodiments of the low profile antennas are configured to emit a detectable signal upon contact with a target physiological site. Also provided are methods of making and using the devices of the invention.

Low profile antenna for in body device

Growing community of inventors

Portola Valley, CA, United States of America

Mark Zdeblick