Micromass UK Limited

Mark William Towers

Paul Robert Murray

Matthew J Henderson

Philippa J Hart

Andrew Whatley

Stevan Bajic

Jeff Brown

Edward Scott

Richard William Jarrold

Steve Brace

Emrys Jones

Arthur Blake

Andrew Pawson

Emmanuelle Claude

Matthew Havard

Gordon Kearney

Philippa Hart

A mass spectrometer is disclosed comprising a rotatable isolation valvehaving a curved, spherical, cylindrical or concave portion. At least a portion of an ion guideis positioned so as to extend within a swept volume of the isolation valveenabling the ion guideto be positioned close to a second downstream ion guideand for ions to be transmitted from the firstion guide to the second ion guidewith high ion transmission efficiency.

Device for rapid exchange of ion sources and ion transmission devices

A nozzle for an ionisation source comprises: a light passage having an inlet end and an outlet end; and a gas flow passage in fluid communication with the light passage, wherein the gas flow passage is configured to convey, in use, a flow of gas into the light passage such that the flow of gas travels substantially towards the outlet end of the light passage.

MALDI nozzle

Scientific instrument

A mass spectrometer is disclosed comprising a rotatable isolation valve () having a curved, spherical, cylindrical or concave portion. At least a portion of an ion guide () is positioned so as to extend within a swept volume of the isolation valve () enabling the ion guide () to be positioned close to a second downstream ion guide () and for ions to be transmitted from the first () ion guide to the second ion guide () with high ion transmission efficiency.

An ambient ionisation ion source is disclosed that comprises a first device arranged and adapted to generate analyte ions from a target and an enclosure surrounding the first device. The enclosure includes one or more gas inlets and one or more gas outlets. The ambient ionisation ion source also comprises a second device arranged and adapted to supply the enclosure with a first gas via the one or more gas inlets such that the enclosure is maintained, in use, at a pressure greater than atmospheric pressure.

Enclosure for ambient ionisation ion source

A mass and/or ion mobility spectrometercomprises a sample platethat supports a target sample. The spectrometerfurther comprises a laser sourcethat generates a series of laser pulsesand a control systemthat moves a focal point of the laser sourcesubstantially continuously across the sample platesuch that respective packets of ions are generated by respective laser pulsesimpinging upon respective locations on the target sample. The control systemperforms plural cycles of ion analysis that each produce a set of spectral data corresponding to one or more of the packets of ions. The spectrometercan provide mass and/or ion mobility spectrometry having increased speed and efficiency.

Sample ionisation using a pulsed laser source

An ion analysis instrument is disclosed comprising an indicator device for providing an indication of a relative positioning of an ion source, a sample, and/or a sampling orifice or capillary of an ion analysis instrument such as a mass or ion mobility spectrometer in order to facilitate re-alignment of one or more of these components following a change. The indicator device comprises a source of electromagnetic radiation such as a pair of lasers or image projection devices.

Ion source alignment

A method of ion mapping is disclosed comprising depositing a sample onto a target surface and separating the sample on the target surface according to a first physico-chemical property in a first dimension and according to a second physico-chemical property in a second dimension. The method further comprises ionising and mass analysing multiple separate regions of the sample so as to generate an ion map of at least a portion of the sample deposited upon the target surface. The sample is deposited onto and separated on the target surface by mechanical, hydrodynamic and/or aerodynamic means.

Two-dimensional separation and imaging technique for the rapid analysis of biological samples

A method of ion mapping is disclosed comprising depositing a sample onto a target surface and separating the sample on the target surface according to a first physico-chemical property in a first dimension and according to a second physico-chemical property in a second dimension. The method further comprises ionizing and mass analyzing multiple separate regions of the sample so as to generate an ion map of at least a portion of the sample deposited upon the target surface. The sample is deposited onto and separated on the target surface by mechanical, hydrodynamic and/or aerodynamic means.

Growing community of inventors

Stockport, United Kingdom

Mark William Towers