Medtronic, Inc.

Medtronic Cv Luxembourg S.a.r.l.

Mark W Torrianni

Eric Richardson

Mark T Stewart

Timothy G Laske

Paul T Rothstein

John R Liddicoat

Carol Elsa Eberhardt

Cynthia T Clague

Patrick T Cahalan

Gopikrishnan Soundararajan

Kshitija P Garde

Marc Hendriks

Michel L Verhoeven

Maura G Donovan

Paul V Trescony

Linda L Cahalan

Randall V Sparer

Asha Shrinivas Nayak

Chris M Coppin

Damian Jelich

Michael M Green

Benedicte Fouache

Rany Huynh

Eric Meyer

Jesus W Casas-Bejar

Mirian Gillissen

Kenny Dang

Hussain Rangwala

Frans M Everaerts

Brian C A Fernandes

Frank J L Everaerts

Wilfred Den Hartog

Frank Everaerts

Verhoeven Michel

Eric A Meyer

Khitija Garde

Asha S Nayak

Damian A Jelich

A method of preventing paravalvular leakage includes concurrent delivery of a heart valve prosthesis and an annular sealing component. During delivery, the sealing component is moved from a first position to a second position of the heart valve prosthesis which is longitudinally spaced apart from the first position of the heart valve prosthesis. The sealing component is secured around the heart valve prosthesis at the second position by a contoured outer surface of the heart valve prosthesis. The sealing component may be a flexible ring or may be a cylindrical flexible sleeve having a plurality of ribs longitudinally extending over the cylindrical sleeve. The ribs operate to deploy the sealing component such that at least a portion of the cylindrical sleeve buckles outwardly away from the outer surface of the heart valve prosthesis.

Transcatheter valve prosthesis and a concurrently delivered sealing component

A transcatheter valve prosthesis includes an expandable tubular stent, a prosthetic valve within the stent, and an anti-paravalvular leakage component coupled to and encircling the tubular stent. The anti-paravalvular leakage component includes a radially-compressible annular scaffold, which is a sinusoidal patterned ring of self-expanding material, and an impermeable membrane extending over the annular scaffold. The anti-paravalvular leakage component has an expanded configuration in which at least segments of the annular scaffold curve radially away from the tubular stent. Alternatively, the anti-paravalvular leakage component includes a plurality of self-expanding segments and an annular sealing element coupled to inner surfaces of the segments. The anti-paravalvular leakage component has an expanded configuration in which the segments curve radially away from the tubular stent and the annular sealing element is positioned between an outer surface of the tubular stent and inner surfaces of the segments.

Anti-paravalvular leakage component for a transcatheter valve prosthesis

A surgical fastener clip for proximating tissue, the clip providing an undeflected state in which the clip comprises a center portion, a first leg, and a second leg. The center portion has a perimeter defining a circle-like shape. The legs project outwardly relative to the perimeter from a point of departure to a tip. Extension of each of the legs relative to the perimeter defines an identical wind direction that is either clockwise or counterclockwise. The clip optionally includes a linear cross-member extending across the perimeter. The surgical clip can be formed by a wire that is partially wound onto itself in a spiral-like fashion, with the center portion and the legs being co-planar in the undeflected state. During use, the clip is rotated, drawing tissue into the center portion. Systems incorporating the clip are also provided.

Surgical fastening clips, systems and methods for proximating tissue

The present invention provides an electrophoretic system, apparatus, and method of use thereof for the preparation of a tissue-derived bioprosthesis.

Process for producing decellularized biological tissues

An implantable medical device comprising a drug-loaded polymer overlaid with a fabric that promotes tissue ingrowth is useful in a wide variety of tissue engineering applications. The invention includes, for example, prosthetic heart valves, annuloplasty rings, and grafts, having enhanced biocompatibility and biostability. Methods of making and using the implantable medical devices of the invention are also included.

Implantable medical device with enhanced biocompatibility and biostability

A method of making a tissue-derived implantable medical device that includes contacting the tissue with a composition comprising at least one oxidizing agent prior to implantation of the medical device.

Process for reducing mineralization of tissue used in transplantation

Methods for making crosslinked material, such as collagen-based material, and bioprosthetic devices. The crosslinked material includes hydroxyl groups, carboxyl groups, and amine groups prior to crosslinking. The methods include removing at least a portion of the zero-length ester crosslinks in a crosslinked material and/or blocking at least a portion of the amine groups that are reactive with carboxyl groups and form zero-length crosslinks.

Methods of preparing crosslinked materials and bioprosthetic devices

Methods for making bioprosthetic devices made of collagen-based material having collagen amine groups and collagen carboxyl groups are provided. The methods include blocking at least a portion of the collagen amine groups with a blocking agent, activating at least a portion of the collagen carboxyl groups after blocking at least a portion of the collagen amine groups to form activated carboxyl groups, and contacting the activated collagen carboxyl groups with a polyfunctional spacer to crosslink the collagen-based material.

Process for making a bioprosthetic device

Growing community of inventors

San Juan Capistrano, CA, United States of America

Mark W Torrianni