Bsi Corporation

Bio-metric Systems, Inc.

Mark W Josephson

Melvin J Swanson

Patrick E Guire

Shawn G Dunkirk

Dale G Swan

Surfaces are provided with desired characteristics of a polymer by covalently bonding polymer molecules to the surface through external activation of latent reactive groups carried by the polymer molecules. The initial surfaces are free of chemical groups added by surface pretreatement and which chemically participate in the covalent bonding process.

Preparation of polymeric surfaces

A chemical specie is immobilized in a three dimensional, crosslinked matrix by bringing together in covalent bonding proximity a desired chemical specie and a polymeric coupling compound such as a photoderivatized polymer having at least two latent photochemical reactive groups per molecule, each latent reactive group being capable when activated of covalently bonding to another coupling compound molecule or to the chemical specie. The chemical specie may be a protein, carbohydrate, nucleic acid or lipid, and desirably is free of latent reactive groups that are activated upon activation of the latent reactive groups of the coupling compound. The latent reactive groups are simultaneously activated to cause formation via covalent bonding of a three-dimensional molecular network in which molecules of the chemical specie are covalently bonded to molecules of the coupling compound, and molecules of the coupling compound are covalently bonded to each other. The matrix containing the covalently bonded chemical specie may be contacted with a different chemical specie under conditions to incorporate the specie into the matrix in unbound form so that it can be gradually released from the matrix. In a preferred embodiment, the covelently bonded chemical specis is an antithrombic agent and the inbound chemical specil is an antibiotic. Preferably, the three dimensional matrix is formed as a coating upon a surface to which covalent bonds are formed upon activation of the latent reactive groups of the coupling compound.

Preparation of crosslinked matrices containing covalently immobilized

Surfaces are provided with desired characteristics of a polymer by covalently bonding polymer molecules to the surface through external activation (e.g., actinic radiation) of latent reactive groups, such as photoactivatable ketones, carried by the polymer molecules. The initial surfaces are free of chemical groups added by surface pretreatement and which chemically participate in the covalent bonding process.

Substrate surface preparation

A method wherein surfaces are provided with desired characteristics of a polymer by covalently bonding polymer molecules to the surface through external activation of latent reactive groups carried by the polymer molecules is disclosed. The initial surfaces are free of chemical groups added by surface pretreatment and which chemically participate in the covalent bonding process.

Growing community of inventors

Richfield, MN, United States of America

Mark W Josephson